atp4a Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-486103

Gene Symbol: atp4a Gene Name: ATPase H+/K+ transporting subunit alpha

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormally decreased number of cilium in the multiciliated cell (3 sources), abnormally decreased number of small secretory cell (3 sources), abnormal cilium assembly (2 sources), abnormally localised gall bladder (2 sources), abnormally localised outflow tract (2 sources), absent gall bladder (2 sources), absent outflow tract (2 sources), decreased length of anterior-posterior axis (2 sources), decreased size of the eye (2 sources), decreased size of the head (2 sources), abnormal bending of tail (1 source), abnormal cell migration in neural crest (1 source), abnormal cilium morphology in the multiciliated epidermal cell (1 source), abnormal development of neural crest (1 source), absent pronephric tubule (1 source), decreased pigmentation in the whole organism (1 source), decreased size of the cilium in the multiciliated epidermal cell (1 source), increased width of neural plate (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormally decreased number of cilium in the multiciliated cell (3 sources), abnormally decreased number of small secretory cell (3 sources), abnormal cilium assembly (2 sources), abnormally localised gall bladder (2 sources), abnormally localised outflow tract (2 sources), absent gall bladder (2 sources), absent outflow tract (2 sources), decreased length of anterior-posterior axis (2 sources), decreased size of the eye (2 sources), decreased size of the head (2 sources), abnormal bending of tail (1 source), abnormal cell migration in neural crest (1 source), abnormal cilium morphology in the multiciliated epidermal cell (1 source), abnormal development of neural crest (1 source), absent pronephric tubule (1 source), decreased pigmentation in the whole organism (1 source), decreased size of the cilium in the multiciliated epidermal cell (1 source), increased width of neural plate (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: atp4a manipulated (27 sources)
Computed annotations: atp4a assayed (4 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
pneumonia (5AP sources, 20 EP sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + atp4a MO + animal cap explant (15 sources), Xla Wt + atp4a MO (6 sources), Xla Wt + atp4a MO (4 sources), Xla Wt + atp4a MO (4 sources), Xla Wt + atp4a MO (4 sources), Xla Wt + atp4a MO (1 source), Xla Wt + atp4a MO (1 source), Xla Wt + atp4a MO (1 source), Xla Wt + atp4a MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (23 sources): abnormal erythropoiesis, abnormal gastric chief cell morphology, abnormal gastric gland morphology, abnormal gastric parietal cell morphology, abnormal stomach enteroendocrine cell morphology, abnormal stomach glandular region morphology, abnormal stomach wall morphology, achlorhydria, decreased circulating ferritin level, decreased circulating iron level, decreased erythrocyte osmotic fragility, decreased hematocrit, decreased hemoglobin content, decreased mean corpuscular hemoglobin, decreased mean corpuscular volume, dilated gastric glands, enlarged stomach, gastric cyst, gastric metaplasia, hematopoietic system phenotype, increased circulating erythropoietin level, increased red blood cell distribution width, increased stomach pH [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (23 sources): abnormal erythropoiesis, abnormal gastric chief cell morphology, abnormal gastric gland morphology, abnormal gastric parietal cell morphology, abnormal stomach enteroendocrine cell morphology, abnormal stomach glandular region morphology, abnormal stomach wall morphology, achlorhydria, decreased circulating ferritin level, decreased circulating iron level, [+]