fgf10 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-485043

Gene Symbol: fgf10 Gene Name: fibroblast growth factor 10

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal digit-joint region (1 source), abnormal digit-joint region morphology in the regenerating forelimb (1 source), abnormal forelimb digit (1 source), abnormal regenerating forelimb (1 source), abnormal regenerating forelimb morphology (1 source), abnormally decreased number of digit-joint region in the regenerating forelimb (1 source), increased branchiness of regenerating forelimb (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal digit-joint region (1 source), abnormal digit-joint region morphology in the regenerating forelimb (1 source), abnormal forelimb digit (1 source), abnormal regenerating forelimb (1 source), abnormal regenerating forelimb morphology (1 source), abnormally decreased number of digit-joint region in the regenerating forelimb (1 source), increased branchiness of regenerating forelimb (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: fgf10 assayed (1 source)
Computed annotations: fgf10 assayed (7 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + Hsa.FGF10 + Hsa.SHH + TMSB4X + forelimb amputation (2 sources), Xla Wt + Hsa.FGF10 + Hsa.SHH + forelimb amputation (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (42 sources): 2-3 finger syndactyly, Absence of Stensen duct, Absent lacrimal punctum, Absent proximal phalanx of thumb, Absent radius, Alacrima, Aplasia of the parotid gland, Bilateral triphalangeal thumbs, Broad forehead, Broad hallux, Carious teeth, Clinodactyly of the 5th finger, Conical incisor, Corneal perforation, Coronal hypospadias, Cupped ear, Dacryocystitis, Delayed eruption of primary teeth, Downslanted palpebral fissures, Enamel hypoplasia, Hyperextensible skin, Hypertelorism, Hypodontia, Hypoplasia of the lacrimal punctum, Hypoplasia of the radius, Hypoplasia of the ulna, Hypoplastic lacrimal duct, Lacrimal gland aplasia, Lacrimal gland hypoplasia, Limbal stem cell deficiency, Mixed hearing impairment, Nasolacrimal duct obstruction, Nephrosclerosis, Partial duplication of thumb phalanx, Periorbital fullness, Preaxial polydactyly, Radial deviation of the 3rd finger, Recurrent corneal erosions, Renal agenesis, Small thenar eminence, Telecanthus, Xerostomia [+]
Mouse (110 sources): Harderian gland atrophy, abnormal Rathke's pouch apoptosis, abnormal Wolffian duct morphology, abnormal branching involved in trachea morphogenesis, abnormal branching of the mammary ductal tree, abnormal cecum development, abnormal cochlea morphology, abnormal colon morphology, abnormal crista ampullaris morphology, abnormal ear morphology, abnormal embryo development, abnormal embryonic tissue morphology, abnormal forced expiratory flow rates, abnormal gastric chief cell morphology, abnormal grip strength, abnormal hair follicle morphology, abnormal heart atrium auricular region morphology, abnormal heart position or orientation, abnormal hindgut morphology, abnormal hypaxial muscle morphology, abnormal inner ear canal morphology, abnormal intestinal epithelium morphology, abnormal kidney inner medulla morphology, abnormal kidney outer medulla morphology, abnormal large intestine crypts of Lieberkuhn morphology, abnormal lateral nasal gland morphology, abnormal lens epithelium morphology, abnormal lens fiber morphology, abnormal limb bud morphology, abnormal limb development, abnormal lung development, abnormal mammary fat pad morphology, abnormal mammary placode morphology, abnormal metanephric ureteric bud development, abnormal nasal gland morphology, abnormal neurohypophysis development, abnormal palate morphology, abnormal periderm development, abnormal primitive urogenital sinus morphology, abnormal prostate gland morphology, abnormal pulmonary elastic fiber morphology, abnormal pulmonary trunk morphology, abnormal retina apoptosis, abnormal secondary palate development, abnormal sensory neuron innervation pattern, abnormal stomach submucosa morphology, abnormal sublingual gland morphology, abnormal submandibular duct morphology, abnormal submandibular gland development, abnormal vestibular hair cell kinocilium morphology, abnormal vestibular hair cell stereociliary bundle morphology, absent Harderian gland, absent Rathke's pouch, absent adenohypophysis, absent bulbourethral gland, absent colon, absent forelimb, absent hindlimb, absent limb buds, absent limbs, absent lung buds, absent lungs, absent palatal rugae, absent posterior semicircular canal, absent prostate gland, absent pulmonary vein, absent rectum, absent salivary gland, absent seminal vesicle, absent submandibular gland, absent superior semicircular canal, cecal atresia, decreased colon length, decreased fetal size, decreased grip strength, decreased hair follicle number, decreased lateral semicircular canal size, decreased lean body mass, decreased salivation, decreased submandibular gland size, decreased trachea gland number, dilated kidney calyx, eyelids open at birth, impaired branching involved in bronchus morphogenesis, impaired branching involved in preterminal bronchiole morphogenesis, impaired lung alveolus development, increased hair follicle apoptosis, increased total body fat amount, muscle phenotype, neonatal lethality, complete penetrance, no abnormal phenotype detected, palatal shelf fusion with tongue or mandible, perinatal lethality, complete penetrance, prenatal lethality, complete penetrance, preweaning lethality, complete penetrance, reduced enamel thickness, short incisors, small hair follicle bulb, small kidney, small lung, small molars, small otic capsule, small pancreas, small salivary gland, small stomach, small thymus, small vestibular saccule, submandibular gland hypoplasia, thin epidermis, vision/eye phenotype [+]
View all ortholog results at Monarch