sox3 Phenotypes

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Phenotypes

Gene Literature (264)

Nucleotides (594)

Interactants (1401)

XB-GENEPAGE-484814

Gene Symbol: sox3 Gene Name: SRY-box 3

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: sox3 manipulated (1 source), sox3 assayed (29 sources)
Computed annotations: sox3 manipulated (3 sources), sox3 assayed (4 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Wt + pou5f3.2 MO + pou5f3.3 MO + sox3 MO (3 sources), Xla Wt + sox3 (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (80 sources): Abnormal cardiovascular system morphology, Abnormal prolactin level, Abnormality of secondary sexual hair, Abnormality of the hypothalamus-pituitary axis, Absence of secondary sex characteristics, Absent septum pellucidum, Agenesis of corpus callosum, Ambiguous genitalia, Amenorrhea, Anosmia, Anterior pituitary hypoplasia, Aplasia/Hypoplasia of the breasts, Aplasia/Hypoplasia of the cerebellum, Autism, Azoospermia, Bicornuate uterus, Cleft palate, Clitoral hypertrophy, Congenital, generalized hypertrichosis, Constipation, Cryptorchidism, Decreased circulating ACTH level, Decreased response to growth hormone stimulation test, Decreased testicular size, Delayed puberty, Delayed skeletal maturation, Depressed nasal ridge, Diabetes insipidus, Dry skin, Ectopic anterior pituitary gland, Ectopic posterior pituitary, Elevated circulating follicle stimulating hormone level, Elevated circulating luteinizing hormone level, Esophageal atresia, Fatigue, Global developmental delay, Growth delay, Gynecomastia, Hemiplegia/hemiparesis, Hirsutism, Hypoglycemia, Hypogonadotropic hypogonadism, Hypohidrosis, Hypopituitarism, Hypoplasia of penis, Hypospadias, Hypotension, Hypothyroidism, Infertility, Intellectual disability, Intellectual disability, mild, Male hypogonadism, Maternal diabetes, Nystagmus, Obesity, Optic disc hypoplasia, Optic nerve hypoplasia, Osteopenia, Osteoporosis of vertebrae, Ovotestis, Panhypopituitarism, Pituitary dwarfism, Pituitary hypothyroidism, Polycystic ovaries, Polydactyly, Polydipsia, Psychomotor retardation, Scoliosis, Seizure, Sensorineural hearing impairment, Septo-optic dysplasia, Sex reversal, Short finger, Short stature, Sleep disturbance, Strabismus, Tall stature, Tracheoesophageal fistula, True hermaphroditism, Visual impairment [+]
Mouse (39 sources): abnormal Rathke's pouch development, abnormal Sertoli cell morphology, abnormal adenohypophysis development, abnormal brain commissure morphology, abnormal craniofacial morphology, abnormal diencephalon morphology, abnormal female reproductive system morphology, abnormal hippocampal commissure morphology, abnormal oocyte morphology, abnormal ovarian follicle morphology, abnormal ovarian folliculogenesis, abnormal pituitary infundibular stalk morphology, abnormal posterior commissure morphology, abnormal roof plate morphology, abnormal seminiferous tubule morphology, abnormal subcommissural organ morphology, abnormal third ventricle morphology, absent pineal gland, absent pineal recess, absent pituitary infundibular stalk, behavior/neurological phenotype, bifurcated Rathke's pouch, cellular phenotype, decreased follicle stimulating hormone level, decreased germ cell number, decreased growth hormone level, decreased testis weight, decreased thyroid-stimulating hormone level, domed cranium, embryo phenotype, enlarged lateral ventricles, enlarged third ventricle, increased cell proliferation, nervous system phenotype, postnatal lethality, postnatal lethality, incomplete penetrance, reduced female fertility, reproductive system phenotype, small ovary [+]
View all ortholog results at Monarch