grem1 Phenotypes

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Phenotypes

Gene Literature (39)

Nucleotides (73)

Interactants (321)

XB-GENEPAGE-484542

Gene Symbol: grem1 Gene Name: gremlin 1, DAN family BMP antagonist

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: grem1 manipulated (3 sources), grem1 assayed (2 sources)
Computed annotations: grem1 assayed (4 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + grem1 (1 source), Xla Wt + grem1 MO (1 source), Xla Wt + Mmu.grem1 (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (18 sources): Abnormal bleeding, Adenocarcinoma of the colon, Adenomatous colonic polyposis, Colon cancer, Colorectal polyposis, Desmoid tumors, Duodenal adenocarcinoma, Endometrial carcinoma, Hematochezia, Hyperplastic colonic polyposis, Intussusception, Juvenile colonic polyposis, Neoplasm of the gastrointestinal tract, Neoplasm of the rectum, Prostate cancer, Rectal polyposis, Refractory anemia, Thyroid carcinoma [+]
Mouse (29 sources): abnormal apical ectodermal ridge morphology, abnormal forelimb morphology, abnormal hindlimb morphology, abnormal kidney morphology, abnormal limb bud morphology, abnormal limb development, abnormal limb long bone morphology, abnormal limb mesenchyme morphology, abnormal limb morphology, abnormal lung epithelium morphology, abnormal metanephric mesenchyme morphology, abnormal pulmonary alveolus morphology, abnormal ureteric bud elongation, abnormal ureteric bud invasion, absent metanephros, absent ureter, enhanced osteoblast differentiation, fused radius and ulna, impaired branching involved in ureteric bud morphogenesis, increased apoptosis, increased bone mineralization, increased bone ossification, increased metanephric mesenchyme apoptosis, increased trabecular bone thickness, increased trabecular bone volume, neonatal lethality, complete penetrance, postnatal lethality, complete penetrance, renal/urinary system phenotype, reproductive system phenotype [+]
View all ortholog results at Monarch