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XB-GENEPAGE-484424
ptf1a pancreas associated transcription factor 1a
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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increased size of the pancreas (8 sources), abnormal duodenum morphology (3 sources), abnormal stomach morphology (3 sources), decreased size of the duodenum (3 sources), decreased size of the pancreas (3 sources), decreased size of the stomach (3 sources), abnormal development of pancreas (2 sources), abnormal bending of tail (1 source), abnormal endoderm morphology (1 source), abnormal gastrulation (1 source), abnormal pancreas morphology (1 source), absent pancreas (1 source) |
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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Manual annotations: ptf1a manipulated (46 sources), ptf1a assayed (8 sources) |
Computed annotations: ptf1a assayed (12 sources) |
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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Xla Wt + ptf1a-GR + DEX (7 sources), Xla Wt + ptf1a MO (5 sources), Xla Wt + pdx1-GR + ptf1a-GR + DEX (4 sources), Xla Wt + ptf1a-GR + DEX (4 sources), Xla Wt + ptf1a-VP16 (4 sources), Xla Wt + ptf1a (3 sources), Xla Wt + ptf1a MO (3 sources), Xla Wt + ptf1a-GR + DEX (3 sources), Xla Wt + ptf1a-GR + DEX (3 sources), Xla Wt + ptf1a-GR + DEX (3 sources), Xtr Wt + ptf1a CRISPR (3 sources), Xla Wt + ptf1a gRNA2/3 CRISPR (2 sources), Xla Wt + ptf1a-GR + DEX (2 sources), Xla Wt + ptf1a-neurog2-GR + DEX (2 sources), Xla Wt + pdx1 MO + ptf1a MO (1 source), Xla Wt + ptf1a + rbpj (1 source), Xla Wt + ptf1a gRNA2 CRISPR (1 source), Xla Wt + ptf1a gRNA3 CRISPR (1 source), Xla Wt + ptf1a-GR + CHX + DEX (1 source), Xla Wt + ptf1a-GR + DEX (1 source), Xla Wt + ptf1a-GR + DEX (1 source), Xtr Wt + ptf1a CRISPR (1 source) |
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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Human (27 sources): Abnormality of the pinna, Anemia, Aplasia/Hypoplasia of the pancreas, Apnea, Cerebellar agenesis, Cerebellar hypoplasia, Convex nasal ridge, Diabetes mellitus, Failure to thrive, Hyperglycemia, [+] |
Mouse (19 sources): abnormal cerebellar granule layer morphology, abnormal cerebellum development, abnormal eye development, abnormal glutaminergic neuron morphology, abnormal neuron differentiation, abnormal pancreas development, abnormal retina outer plexiform layer morphology, abnormal spinal cord dorsal horn morphology, absent amacrine cells, absent cerebellum, [+] |
View all ortholog results at Monarch |