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Summary Expression Phenotypes Gene Literature (95) GO Terms (20) Nucleotides (139) Proteins (100) Interactants (849) Wiki

pax8     paired box 8

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal pronephric kidney morphology (3 sources), abnormal development of pronephric kidney (2 sources), abnormal proximal tubule morphology (1 source), absent pronephric tubule (1 source), absent proximal tubule (1 source), edematous ventral trunk (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: pax8 manipulated (9 sources), pax8 assayed (5 sources)
Computed annotations: pax8 assayed (11 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + pax8 MO (10 sources), Xla Wt + pax8 + CHX + DEX + animal cap amputation (1 source), Xtr Wt + pax8 CRISPR (1 source), Xtr Wt + pax8 MO (1 source), Xtr Wt + pax8 MO (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (36 sources): Abdominal distention, Abnormality of the face, Abnormality of the thyroid gland, Bradycardia, Coarse facial features, Congenital hypothyroidism, Constipation, Delayed skeletal maturation, Dry skin, Ectopic thyroid, [+]
Mouse (68 sources): abnormal Mullerian duct morphology, abnormal action potential, abnormal adenohypophysis morphology, abnormal auditory bulla morphology, abnormal bone remodeling, abnormal caput epididymis morphology, abnormal cochlear IHC efferent innervation pattern, abnormal cochlear hair cell morphology, abnormal cochlear hair cell stereociliary bundle morphology, abnormal cochlear inner hair cell physiology, [+]

View all ortholog results at Monarch