Elevated circulating thyroid-stimulating hormone concentration, Fatigue, Feeding difficulties, Feeding difficulties in infancy, Generalized hypotonia, Global developmental delay, Goiter, Growth delay, Hoarse cry, Hyperbilirubinemia, Hypersomnia, Hypothermia, Hypothyroidism, Hypotonia, Intellectual disability, severe, Jaundice, Large fontanelles, Large posterior fontanelle, Lethargy, Macroglossia, Muscle weakness, Short stature, Stridor, Thyroid agenesis, Thyroid hypoplasia, Umbilical hernia

abnormal corpus epididymis morphology, abnormal epididymis epithelium morphology, abnormal epiphyseal plate morphology, abnormal external auditory canal morphology, abnormal inner hair cell synaptic ribbon morphology, abnormal kinocilium morphology, abnormal middle ear ossicle morphology, abnormal organ of Corti morphology, abnormal outer ear morphology, abnormal outer hair cell stereociliary bundle morphology, abnormal pillar cell morphology, abnormal stapedial artery morphology, abnormal stapes crus morpholgy, abnormal thyroid diverticulum morphology, abnormal thyroid follicle morphology, abnormal thyroid follicular cell morphology, abnormal thyroid gland development, abnormal uterus development, absent efferent ductules of testis, absent endometrium, absent epididymis, absent round window, absent stapedial artery, absent thyroid follicular cells, absent uterine horn, arrest of spermatogenesis, cochlear outer hair cell degeneration, deafness, decreased body size, decreased bone mineral density of femur, decreased bone mineralization, decreased bone volume, decreased circulating thyroxine level, decreased femur compact bone thickness, decreased lactotroph cell number, decreased somatotroph cell number, decreased testis weight, delayed bone ossification, delayed ear emergence, delayed endochondral bone ossification, delayed eyelid opening, delayed inner ear development, dilated oviduct, dilated uterine cervix, enlarged tectorial membrane, increased apoptosis, increased circulating thyroid-stimulating hormone level, increased or absent threshold for auditory brainstem response, increased thyroid-stimulating hormone level, increased thyrotroph cell number, lethality at weaning, complete penetrance, no abnormal phenotype detected, postnatal lethality, complete penetrance, premature death, small epididymis, small round window, small thyroid gland, thin myometrium