bmpr1b Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-483454

Gene Symbol: bmpr1b Gene Name: bone morphogenetic protein receptor type 1B

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
increased pigmentation in the head (4 sources), abnormally incomplete structure of head (3 sources), decreased pigmentation in the eye (3 sources), abnormal branchial arch morphology (2 sources), abnormal cartilage element morphology (2 sources), abnormal ceratohyal morphology (2 sources), abnormal ventral tail fin morphology (2 sources), abnormally localised dorsal fin (2 sources), abnormally localised melanophore in dorsal fin (2 sources), absent branchial arch (2 sources), absent cartilage element in the branchial arch (2 sources), absent ceratohyal (2 sources), absent intercanthal region (2 sources), decreased size of the branchial arch (2 sources), decreased width of the cartilage element in head (2 sources), decreased width of the head (2 sources), abnormal cell migration in neural crest (1 source), wholly anteriorized tadpole (1 source), wholly dorsalized embryo (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

increased pigmentation in the head (4 sources), abnormally incomplete structure of head (3 sources), decreased pigmentation in the eye (3 sources), abnormal branchial arch morphology (2 sources), abnormal cartilage element morphology (2 sources), abnormal ceratohyal morphology (2 sources), abnormal ventral tail fin morphology (2 sources), abnormally localised dorsal fin (2 sources), abnormally localised melanophore in dorsal fin (2 sources), absent branchial arch (2 sources), absent cartilage element in the branchial arch (2 sources), absent ceratohyal (2 sources), absent intercanthal region (2 sources), decreased size of the branchial arch (2 sources), decreased width of the cartilage element in head (2 sources), decreased width of the head (2 sources), abnormal cell migration in neural crest (1 source), wholly anteriorized tadpole (1 source), wholly dorsalized embryo (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: bmpr1b manipulated (5 sources)
Computed annotations: bmpr1b assayed (8 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + bmpr1b MO (7 sources), Xla Wt + bmpr1b MO (4 sources), Xla Wt + bmpr1b MO (2 sources), Xla Wt + bmpr1a MO + bmpr1b MO (1 source), Xla Wt + bmpr1b MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (90 sources): 2-3 toe syndactyly, Abnormal hip bone morphology, Abnormal thumb morphology, Abnormality of epiphysis morphology, Abnormality of the radius, Abnormality of the ulna, Abnormality of tibia morphology, Acromesomelia, Aplasia of the fingers, Aplasia of the middle phalanges of the toes, Aplasia of the proximal phalanges of the hand, Aplasia/Hypoplasia involving the metacarpal bones, Aplasia/Hypoplasia of metatarsal bones, Aplasia/Hypoplasia of the fibula, Aplasia/Hypoplasia of the middle phalanx of the 2nd finger, Aplasia/Hypoplasia of the middle phalanx of the 5th finger, Aplasia/Hypoplasia of the patella, Aplasia/Hypoplasia of the thumb, Aplastic/hypoplastic toenail, Bilateral single transverse palmar creases, Bowing of the long bones, Brachydactyly, Broad foot, Broad hallux, Broad metacarpals, Carpal synostosis, Clinodactyly of the 5th finger, Cone-shaped epiphysis, Deformed tarsal bones, Delayed speech and language development, Deviation of finger, Disproportionate short-limb short stature, Distal symphalangism of hands, Fibular aplasia, Fibular hypoplasia, Flexion contracture, Hallux valgus, Hypergonadotropic hypogonadism, Hypoplasia of the radius, Hypoplasia of the ulna, Hypoplasia of the uterus, Joint stiffness, Limitation of joint mobility, Malaligned carpal bone, Medially deviated second toe, Micromelia, Narrow nasal bridge, Patellar dislocation, Pes valgus, Poor motor coordination, Postaxial hand polydactyly, Primary amenorrhea, Radial deviation of finger, Radial deviation of the 2nd finger, Rhizomelia, Sarcoma, Scoliosis, Short 2nd finger, Short 2nd metacarpal, Short distal phalanx of the 2nd finger, Short distal phalanx of the thumb, Short femoral neck, Short femur, Short finger, Short foot, Short hallux, Short humerus, Short metacarpal, Short metatarsal, Short middle phalanx of finger, Short middle phalanx of the 5th finger, Short phalanx of finger, Short proximal phalanx of finger, Short proximal phalanx of thumb, Short stature, Short thumb, Short tibia, Short toe, Skeletal dysplasia, Small nail, Synostosis of carpal bones, Talipes equinovalgus, Talipes equinovarus, Tarsal synostosis, Triangular shaped middle phalanx of the 2nd finger, Triangular shaped middle phalanx of the 5th finger, Type A2 brachydactyly, Ulnar deviation of the 2nd finger, Valgus hand deformity, Widened proximal tibial metaphyses [+]
Mouse (19 sources): abnormal axon guidance, abnormal cartilage development, abnormal chondrocyte differentiation, abnormal digit development, abnormal endometrial gland development, abnormal metacarpal bone morphology, abnormal phalanx morphology, abnormal retina ganglion cell morphology, absent cumulus expansion, absent endometrial glands, decreased cell proliferation, decreased sternebra size, elbow dislocation, fused phalanges, increased apoptosis, increased retina apoptosis, no abnormal phenotype detected, prolonged diestrus, thin endometrium [+]
View all ortholog results at Monarch