cdx2 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-483305

Gene Symbol: cdx2 Gene Name: caudal type homeobox 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: cdx2 assayed (1 source)
Computed annotations: cdx2 manipulated (2 sources), cdx2 assayed (25 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + cdx1 MO + Cdx2 MO + Cdx4 MO (1 source), Xtr Wt + Cdx2 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (61 sources): abnormal Paneth cell physiology, abnormal blastocoele morphology, abnormal blastocyst morphology, abnormal cecum morphology, abnormal cell cycle checkpoint function, abnormal cell migration, abnormal chromosome morphology, abnormal colon morphology, abnormal crypts of Lieberkuhn morphology, abnormal digestive system development, abnormal duodenum morphology, abnormal enteroendocrine cell morphology, abnormal hindgut morphology, abnormal inner cell mass apoptosis, abnormal intestinal epithelium morphology, abnormal intestinal goblet cell morphology, abnormal intestinal mucosa morphology, abnormal intestine physiology, abnormal mesoderm development, abnormal placenta labyrinth morphology, abnormal presomitic mesoderm morphology, abnormal trophectoderm morphology, abnormal trophoblast layer morphology, absent colon, absent enterocytes, absent hindlimb buds, absent inner cell mass proliferation, absent tail, absent trophoblast giant cells, caudal body truncation, cecum polyps, cervical vertebral transformation, colon polyps, decreased apoptosis, decreased body size, decreased small intestinal villus size, decreased somite size, distended duodenum, embryonic growth arrest, embryonic lethality before implantation, complete penetrance, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality during organogenesis, complete penetrance, embryonic lethality, complete penetrance, failure of blastocyst to hatch from the zona pellucida, failure of chorioallantoic fusion, failure of embryo implantation, impaired somite development, increased Paneth cell number, increased apoptosis, increased colon adenoma incidence, increased colon hamartoma incidence, increased intestinal adenoma incidence, increased trophectoderm apoptosis, kinked tail, neonatal lethality, complete penetrance, no abnormal phenotype detected, reproductive system phenotype, short rostral-caudal axis, short tail, thoracic vertebral transformation, vertebral transformation [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (61 sources): abnormal Paneth cell physiology, abnormal blastocoele morphology, abnormal blastocyst morphology, abnormal cecum morphology, abnormal cell cycle checkpoint function, abnormal cell migration, abnormal chromosome morphology, abnormal colon morphology, abnormal crypts of Lieberkuhn morphology, abnormal digestive system development, [+]