| Monarch Ortholog Phenotypes
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Human (2 sources):
Ischemic stroke,
Sensorineural hearing impairment
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Mouse (25 sources):
abnormal cochlear hair cell stereociliary bundle morphology,
abnormal cochlear microphonics,
abnormal cochlear outer hair cell physiology,
abnormal distortion product otoacoustic emission,
abnormal hair cell mechanoelectric transduction,
abnormal hearing physiology,
abnormal Hensen stripe morphology,
abnormal Kimura membrane morphology,
abnormal otoacoustic response,
abnormal otolithic membrane morphology,
abnormal tectorial membrane covernet morphology,
abnormal tectorial membrane marginal band morphology,
abnormal tectorial membrane morphology,
abnormal tectorial membrane striated-sheet matrix morphology,
absent distortion product otoacoustic emissions,
absent Hensen stripe,
audiogenic seizures,
behavior/neurological phenotype,
decreased cochlear microphonics,
decreased cochlear nerve compound action potential,
decreased otolith number,
detached tectorial membrane,
enlarged otoliths,
hearing/vestibular/ear phenotype,
increased or absent threshold for auditory brainstem response
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.