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XB-GENEPAGE-483145
six6 SIX homeobox 6
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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| abnormal eye (4 sources), decreased size of the eye (2 sources), increased size of the eye (2 sources) |
| Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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| Manual annotations: six6 assayed (1 source) |
| Computed annotations: six6 assayed (6 sources) |
| Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes
from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
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| microphthalmia (2AP sources) |
| Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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| Xtr Wt + six6.L CRISPR + GFP (1 source), Xtr Wt + six6.S CRISPR + GFP (1 source), Xtr wt + Xla.six6.L mRNA (1 source), Xtr wt + Xla.six6.S mRNA (1 source) |
| Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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| Human (11 sources): Cataract, Chorioretinal coloboma, Glaucoma, Horizontal nystagmus, Iris coloboma, Macular atrophy, Microphthalmia, Miosis, Nystagmus, Retinal detachment, [+] |
| Mouse (1 source): abnormal retina ganglion layer morphology |
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View all ortholog results at Monarch |