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Summary Expression Phenotypes Gene Literature (141) GO Terms (6) Nucleotides (164) Proteins (70) Interactants (1213) Wiki

pitx2     paired like homeodomain 2

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal stomach morphology (10 sources), abnormal foregut endoderm morphology (3 sources), abnormal stomach epithelium (2 sources)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: pitx2 manipulated (1 source), pitx2 assayed (45 sources)
Computed annotations: pitx2 assayed (34 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + pitx2 + DEX (3 sources), Xla Wt + pitx2 MOs (3 sources), Xla Wt + pitx2 gRNA1 CRISPR (2 sources), Xla Wt + pitx2 gRNA2 CRISPR (1 source), Xla Wt + pitx2 MO (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (45 sources): Abnormal anterior chamber morphology, Abnormal conjunctiva morphology, Abnormal cornea morphology, Abnormal facial shape, Abnormality of cardiovascular system morphology, Abnormality of the abdominal wall, Abnormality of the corneal limbus, Abnormality of the dentition, Abnormality of the hypothalamus-pituitary axis, Abnormally prominent line of Schwalbe, [+]
Mouse (102 sources): abnormal Rathke's pouch apoptosis, abnormal Rathke's pouch development, abnormal adenohypophysis development, abnormal adenohypophysis morphology, abnormal atrioventricular cushion morphology, abnormal atrioventricular valve morphology, abnormal azygos vein morphology, abnormal cardiac outflow tract development, abnormal cell migration, abnormal cone electrophysiology, [+]

View all ortholog results at Monarch