lhx1 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (220)

XB-GENEPAGE-482481

Gene Symbol: lhx1 Gene Name: LIM homeobox 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
duplicated main body axis (6 sources), absent eye (5 sources), duplicated head (5 sources), abnormal eye morphology (4 sources), abnormal retina morphology (4 sources), abnormal gastrulation (3 sources), abnormal head morphology (3 sources), absent head (3 sources), abnormal tail morphology (2 sources), decreased size of the eye (2 sources), duplicated eye (2 sources), abnormal embryo morphology (1 source), abnormal forebrain (1 source), abnormal foregut morphology (1 source), abnormally delayed closure of blastopore (1 source), abnormal tail bud morphology (1 source), abnormal ventral trunk morphology (1 source), absent optic stalk (1 source), decreased length of anterior-posterior axis (1 source), decreased size of the forebrain (1 source), decreased size of the midbrain-hindbrain boundary (1 source), fused eyes (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

duplicated main body axis (6 sources), absent eye (5 sources), duplicated head (5 sources), abnormal eye morphology (4 sources), abnormal retina morphology (4 sources), abnormal gastrulation (3 sources), abnormal head morphology (3 sources), absent head (3 sources), abnormal tail morphology (2 sources), decreased size of the eye (2 sources), duplicated eye (2 sources), abnormal embryo morphology (1 source), abnormal forebrain (1 source), abnormal foregut morphology (1 source), abnormally delayed closure of blastopore (1 source), abnormal tail bud morphology (1 source), abnormal ventral trunk morphology (1 source), absent optic stalk (1 source), decreased length of anterior-posterior axis (1 source), decreased size of the forebrain (1 source), decreased size of the midbrain-hindbrain boundary (1 source), fused eyes (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: lhx1 manipulated (7 sources), lhx1 assayed (23 sources)
Computed annotations: lhx1 assayed (33 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + tle1 + gsc + otx2 + ssbp3 + ldb1 + lhx1 mRNA (3 sources), Xtr Wt + otx2 MO + crx MO + gsc MO + lhx1 MO (3 sources), Xla Wt + lhx1 MO + otx2 MO (2 sources), Xtr Wt + lhx1 MO (2 sources), Xla Wt + gsc + ssbp3 + tle1 + lhx1 mRNA 5 (1 source), Xla Wt + lhx1 MO (1 source), Xla Wt + lhx1 MO (1 source), Xla Wt + lhx1 MO + otx2 MO (1 source), Xla Wt + lhx1 + otx2 (1 source), Xla Wt + lhx1 + otx2 + sia1 MO + sia2 MO (1 source), Xla Wt + otx2 + ssbp3 + ldb1 + lhx1 (1 source), Xla Wt + otx2 + ssbp3 + ldb1 + lhx1 mRNA (1 source), Xtr Wt + crx MO + otx2 MO + lhx1 MO (1 source), Xtr Wt + lhx1 MO (1 source), Xtr Wt + lhx1 MO + gsc MO (1 source), Xtr Wt + ssbp3 + ldb1 + lhx1 mRNA (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xla Wt + tle1 + gsc + otx2 + ssbp3 + ldb1 + lhx1 mRNA (3 sources), Xtr Wt + otx2 MO + crx MO + gsc MO + lhx1 MO (3 sources), Xla Wt + lhx1 MO + otx2 MO (2 sources), Xtr Wt + lhx1 MO (2 sources), Xla Wt + gsc + ssbp3 + tle1 + lhx1 mRNA 5 (1 source), Xla Wt + lhx1 MO (1 source), Xla Wt + lhx1 MO (1 source), Xla Wt + lhx1 MO + otx2 MO (1 source), Xla Wt + lhx1 + otx2 (1 source), Xla Wt + lhx1 + otx2 + sia1 MO + sia2 MO (1 source), Xla Wt + otx2 + ssbp3 + ldb1 + lhx1 (1 source), Xla Wt + otx2 + ssbp3 + ldb1 + lhx1 mRNA (1 source), Xtr Wt + crx MO + otx2 MO + lhx1 MO (1 source), Xtr Wt + lhx1 MO (1 source), Xtr Wt + lhx1 MO + gsc MO (1 source), Xtr Wt + ssbp3 + ldb1 + lhx1 mRNA (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (62 sources): abnormal allantois morphology, abnormal anterior head development, abnormal brain development, abnormal egg cylinder morphology, abnormal endoderm development, abnormal female reproductive system morphology, abnormal gastrulation movements, abnormal heart looping, abnormal hindbrain development, abnormal kidney development, abnormal kidney medulla development, abnormal kidney morphology, abnormal mesonephros morphology, abnormal Mullerian duct morphology, abnormal nervous system development, abnormal primitive node morphology, abnormal primitive streak elongation, abnormal primitive streak formation, abnormal rostral-caudal axis patterning, abnormal ureter development, abnormal ureteric bud elongation, abnormal ureteric bud morphology, abnormal Wolffian duct morphology, absent epididymis, absent forebrain, absent metanephros, absent Mullerian ducts, absent nephron, absent prechordal mesoderm, absent renal glomerulus, absent testes, absent ureter, acephaly, agonadal, cardia bifida, cellular necrosis, decreased circulating alkaline phosphatase level, decreased embryo size, decreased renal glomerulus number, dilated allantois, duplex kidney, ectopic ureter, embryonic-extraembryonic boundary constriction, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, enlarged pericardium, failure of intramembranous bone ossification, frontal bone foramen, impaired branching involved in ureteric bud morphogenesis, incomplete embryo turning, Mullerian duct degeneration, neonatal lethality, complete penetrance, no abnormal phenotype detected, perinatal lethality, complete penetrance, rostral-caudal axis duplication, rudimentary Mullerian ducts, rudimentary Wolffian ducts, small allantois, small kidney, small metanephros, Wolffian duct degeneration [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (62 sources): abnormal allantois morphology, abnormal anterior head development, abnormal brain development, abnormal egg cylinder morphology, abnormal endoderm development, abnormal female reproductive system morphology, abnormal gastrulation movements, abnormal heart looping, abnormal hindbrain development, abnormal kidney development, [+]