lrp6 Phenotypes

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Phenotypes

Gene Literature (120)

Nucleotides (156)

Interactants (635)

XB-GENEPAGE-481819

Gene Symbol: lrp6 Gene Name: LDL receptor related protein 6

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal bending of tail (1 source), abnormally decreased number of melanophore (1 source), decreased size of the anterior-posterior axis (1 source), decreased size of the tail (1 source), increased size of the cement gland (1 source), increased size of the head (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: lrp6 manipulated (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + lrp6 MO (2 sources), Xtr Wt + lrp6 MO (1 source), Xtr Wt + lrp6 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (8 sources): Abnormality of dental morphology, Abnormality of the face, Agenesis of permanent teeth, Hypoplasia of the maxilla, Microdontia, Micrognathia, Oligodontia, Taurodontia
Mouse (78 sources): abnormal brown adipose tissue morphology, abnormal caudal vertebrae morphology, abnormal coat appearance, abnormal cranium morphology, abnormal dorsal-ventral polarity of the somites, abnormal external female genitalia morphology, abnormal external male genitalia morphology, abnormal eye development, abnormal fatty acids level, abnormal forebrain development, abnormal forelimb morphology, abnormal frontal bone morphology, abnormal hindlimb morphology, abnormal limb morphology, abnormal lipid homeostasis, abnormal lumbar vertebrae morphology, abnormal midbrain-hindbrain boundary morphology, abnormal molar cusp morphology, abnormal orientation of outer hair cell stereociliary bundles, abnormal outer ear morphology, abnormal paraxial mesoderm morphology, abnormal sacral vertebrae morphology, abnormal somite development, abnormal tail bud morphology, abnormal tail ring morphology, abnormal telencephalon morphology, abnormal tooth development, abnormal vertebrae development, abnormal vertebral arch morphology, absent apical ectodermal ridge, absent inferior colliculus, absent paraxial mesoderm, caudal vertebral fusion, curly tail, decreased birth body size, decreased body size, decreased circulating glucose level, decreased embryo size, decreased liver triglyceride level, decreased molar number, decreased somite size, decreased susceptibility to diet-induced obesity, decreased susceptibility to induced hypothermia, delayed bone ossification, delayed cranial suture closure, embryonic lethality before implantation, incomplete penetrance, failure of eyelid fusion, forebrain hypoplasia, fused dorsal root ganglion, growth retardation of molars, improved glucose tolerance, incomplete somite formation, increased brown fat cell number, increased cholesterol level, increased circulating VLDL triglyceride level, increased circulating adiponectin level, increased circulating aspartate transaminase level, increased insulin sensitivity, increased liver cholesterol level, increased liver triglyceride level, kinked tail, long upper incisors, neonatal lethality, complete penetrance, neonatal lethality, incomplete penetrance, no abnormal phenotype detected, perinatal lethality, complete penetrance, postnatal lethality, incomplete penetrance, prenatal lethality, prenatal lethality, incomplete penetrance, short incisors, short tail, skeleton phenotype, small caudal vertebrae, small cranium, small molars, small tail bud, spina bifida cystica, thin neurocranium [+]
View all ortholog results at Monarch