dkk1 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (203)

XB-GENEPAGE-481643

Gene Symbol: dkk1 Gene Name: dickkopf WNT signaling pathway inhibitor 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
increased size of the head (5 sources), abnormal head (3 sources), absent tail (3 sources), absent tail bud (3 sources), decreased length of anterior-posterior axis (3 sources), abnormal trunk somite (2 sources), increased size of the cement gland (2 sources), increased size of the foregut (2 sources), obsolete abnormal histone phosphorylation (2 sources), partially dorsalized embryo (2 sources), wholly anteriorized embryo (2 sources), abnormal bending of tail (1 source), abnormal central nervous system (1 source), abnormal cilium assembly (1 source), abnormal development of hindgut (1 source), abnormal foregut epithelium morphology (1 source), abnormally decreased length of hindgut (1 source), abnormally decreased number of cilium in the multiciliated cell (1 source), abnormally decreased number of small secretory cell (1 source), abnormal tail (1 source), abnormal ventral side (1 source), absent head (1 source), absent trunk (1 source), decreased size of the cilium in the multiciliated epidermal cell (1 source), decreased size of the head (1 source), increased size of the brain (1 source), increased size of the dorsal pancreatic bud (1 source), increased size of the liver (1 source), increased size of the ventral pancreatic bud (1 source), increased width of cement gland (1 source), wholly dorsalized embryo (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

increased size of the head (5 sources), abnormal head (3 sources), absent tail (3 sources), absent tail bud (3 sources), decreased length of anterior-posterior axis (3 sources), abnormal trunk somite (2 sources), increased size of the cement gland (2 sources), increased size of the foregut (2 sources), obsolete abnormal histone phosphorylation (2 sources), partially dorsalized embryo (2 sources), wholly anteriorized embryo (2 sources), abnormal bending of tail (1 source), abnormal central nervous system (1 source), abnormal cilium assembly (1 source), abnormal development of hindgut (1 source), abnormal foregut epithelium morphology (1 source), abnormally decreased length of hindgut (1 source), abnormally decreased number of cilium in the multiciliated cell (1 source), abnormally decreased number of small secretory cell (1 source), abnormal tail (1 source), abnormal ventral side (1 source), absent head (1 source), absent trunk (1 source), decreased size of the cilium in the multiciliated epidermal cell (1 source), decreased size of the head (1 source), increased size of the brain (1 source), increased size of the dorsal pancreatic bud (1 source), increased size of the liver (1 source), increased size of the ventral pancreatic bud (1 source), increased width of cement gland (1 source), wholly dorsalized embryo (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: dkk1 manipulated (8 sources), dkk1 assayed (13 sources)
Computed annotations: dkk1 assayed (34 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + dkk1 (3 sources), Xla Wt + Hsa.DKK1 (3 sources), Xla Wt + dkk1 (2 sources), Xla Wt + dkk1 (2 sources), Xla Wt + hwa + dkk1 (2 sources), Xla Wt + dkk1 (1 source), Xla Wt + dkk1 (1 source), Xla Wt + dkk1 (1 source), Xla Wt + dkk1 (1 source), Xla Wt + dkk1 + sfrp5 MO (1 source), Xtr Wt + dkk1 (1 source), Xtr Wt + dkk1 (1 source), Xtr Wt + dkk1 + ventral marginal zone explant (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (52 sources): Abnormality of the clivus, Abnormality of the eleventh cranial nerve, Abnormality of the musculature of the lower limbs, Abnormality of the twelfth cranial nerve, Abnorma vestibulocochlear nerve morphology, Adult onset sensorineural hearing impairment, Anteriorly placed odontoid process, Areflexia of upper limbs, Babinski sign, Basilar impression, Basilar invagination, Brain stem compression, Central sleep apnea, Cervical C2/C3 vertebral fusion, Chiari type I malformation, Cranial nerve compression, Cranial nerve paralysis, Diplopia, Distal peripheral sensory neuropathy, Dysarthria, Dysesthesia, Dysphagia, Fatigable weakness of swallowing muscles, Functional abnormality of the inner ear, Fused cervical vertebrae, Gait ataxia, Headache, Hearing impairment, Hyperacusis, Increased intracranial pressure, Limb muscle weakness, Lower limb hyperreflexia, Lower limb spasticity, Muscle weakness, Myelopathy, Neck pain, Nystagmus, Paresthesia, Photophobia, Progressive cerebellar ataxia, Recurrent paroxysmal headache, Scoliosis, Small flat posterior fossa, Small posterior fossa, Somatic sensory dysfunction, Stiff neck, Syringomyelia, Tinnitus, Unsteady gait, Urinary incontinence, Vertigo, Vocal cord paralysis [+]
Mouse (52 sources): abnormal anterior head development, abnormal bone mineralization, abnormal craniofacial development, abnormal definitive hematopoiesis, abnormal embryonic neuroepithelium morphology, abnormal first pharyngeal arch morphology, abnormal forelimb morphology, abnormal hematopoietic stem cell physiology, abnormal hindlimb morphology, abnormal kidney collecting duct epithelium morphology, abnormal limb bud morphology, abnormal mandibular prominence morphology, abnormal osteoclast physiology, abnormal response to transplant, abnormal skeleton physiology, abnormal telencephalon morphology, absent diencephalon, absent frontonasal prominence, absent hindlimb, absent mandible, absent maxilla, absent nasal bone, absent nasal placodes, absent optic vesicle, caudal body truncation, decreased bone ossification, decreased bone strength, decreased bone trabecula number, decreased forebrain size, decreased midbrain size, decreased osteoblast cell number, decreased trabecular bone connectivity density, decreased trabecular bone volume, decreased urine creatinine level, decreased urine glucose level, decreased urine protein level, decreased urine sodium level, ectopic digits, elongated kidney papilla, impaired osteoblast differentiation, increased bone trabecular spacing, increased common lymphocyte progenitor cell number, increased kidney cell proliferation, increased osteoclast cell number, insensitivity to parathyroid hormone, neonatal lethality, complete penetrance, perinatal lethality, complete penetrance, renal/urinary system phenotype, rostral body truncation, small interparietal bone, small parietal bone, thick apical ectodermal ridge [+]
View all ortholog results at Monarch