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XB-GENEPAGE-481390
smurf2 SMAD specific E3 ubiquitin protein ligase 2
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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| decreased length of anterior-posterior axis (6 sources), decreased size of the anterior-posterior axis (6 sources), decreased size of the head (6 sources), abnormal eye morphology (4 sources), decreased size of the eye (4 sources), decreased size of the tail (3 sources), increased size of the cement gland (3 sources), obsolete duplicated anterior-posterior axis (3 sources), abnormal gastrulation (2 sources), abnormally localised cement gland (2 sources), increased size of the central endoderm (2 sources), wholly anteriorized embryo (2 sources), abnormal bending of anterior-posterior axis (1 source), abnormal dorsal trunk morphology (1 source), duplicated cement gland (1 source) |
| Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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| Manual annotations: smurf2 manipulated (14 sources) |
| Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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| Xla Wt + smurf2 MO (4 sources), Xla Wt + smurf2 MO (4 sources), Xla Wt + smurf2 (3 sources), Xla Wt + smurf2 (3 sources), Xla Wt + smurf1 + smurf2 (2 sources), Xla Wt + smurf2 (2 sources), Xla Wt + smurf2 MO (2 sources), Xla Wt + smurf2 MO (2 sources), Xla Wt + Hsa.smurf2 (1 source), Xla Wt + Hsa.smurf2 (1 source), Xla Wt + smurf1 + smurf2 (1 source), Xla Wt + smurf1 MO + smurf2 MO (1 source), Xla Wt + smurf1 MO + smurf2 MO (1 source), Xla Wt + smurf1 MO + smurf2 MO (1 source), Xla Wt + smurf1 MO + smurf2 MO (1 source), Xla Wt + smurf2 MO (1 source), Xla Wt + smurf2 MO (1 source) |
| Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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| Mouse (9 sources): abnormal tail morphology, delayed cellular replicative senescence, increased B cell derived lymphoma incidence, increased hepatocellular carcinoma incidence, increased lymphoma incidence, increased tumor incidence, kinked tail, no abnormal phenotype detected, preweaning lethality, incomplete penetrance |