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Summary Expression Phenotypes Gene Literature (29) GO Terms (26) Nucleotides (193) Proteins (53) Interactants (408) Wiki

smad6     SMAD family member 6

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal development of embryo (2 sources), decreased length of anterior-posterior axis (1 source), duplicated main body axis (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: smad6 assayed (4 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + smad6 MO (3 sources), Xla Wt + smad6 (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (14 sources): Abnormal left ventricular outflow tract morphology, Aortic aneurysm, Aortic arch aneurysm, Aortic regurgitation, Aortic valve calcification, Aortic valve stenosis, Ascending aortic dissection, Bicuspid aortic valve, Calcification of the aorta, Coarctation of aorta, [+]
Mouse (15 sources): abnormal blood vessel physiology, abnormal cardiac epithelial to mesenchymal transition, abnormal coronary vessel morphology, abnormal endocardium morphology, abnormal thrombosis, abnormal truncus arteriosus septation, d-loop transposition of the great arteries, decreased vasodilation, enlarged mitral valve, enlarged pulmonary valve, [+]

View all ortholog results at Monarch