dll4 Phenotypes

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Phenotypes

Gene Literature (29)

Nucleotides (54)

Interactants (398)

XB-GENEPAGE-480901

Gene Symbol: dll4 Gene Name: delta-like 4

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: dll4 assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (63 sources): Abnormal pulmonary valve morphology, Abnormality of bone mineral density, Abnormality of the lower limb, Abnormality of the metacarpal bones, Abnormality of the upper limb, Absent fingernail, Absent hand, Aplasia cutis congenita, Aplasia cutis congenita of scalp, Aplasia cutis congenita over the scalp vertex, Aplasia of the fingers, Aplasia/Hypoplasia of the skin, Aplastic/hypoplastic toenail, Arteriovenous malformation, Ascites, Brachydactyly, Calvarial skull defect, Cataract, Cirrhosis, Congenital hepatic fibrosis, Congenital localized absence of skin, Cutis marmorata, EEG abnormality, Encephalocele, Esophageal varix, Facial palsy, Failure to thrive, Finger syndactyly, Foot oligodactyly, Gastrointestinal hemorrhage, Hemiparesis, Hepatic fibrosis, Hydrocephalus, Hypoplastic fingernail, Hypoplastic toenails, Intellectual disability, Leukopenia, Microphthalmia, Periventricular leukomalacia, Porencephalic cyst, Portal hypertension, Premature birth, Prolonged bleeding time, Pulmonary arterial hypertension, Pulmonary artery atresia, Renal hypoplasia, Seizure, Short distal phalanx of finger, Skin ulcer, Sparse hair, Spasticity, Spinal dysraphism, Split hand, Strabismus, Syndactyly, Talipes equinovarus, Tetralogy of Fallot, Thrombocytopenia, Toe syndactyly, Tricuspid regurgitation, Truncus arteriosus, Ventricular septal defect, obsolete Hypotrichosis [+]
Mouse (43 sources): abnormal T cell differentiation, abnormal angiogenesis, abnormal anterior cardinal vein morphology, abnormal artery development, abnormal artery morphology, abnormal cardinal vein morphology, abnormal common cardinal vein morphology, abnormal dorsal aorta morphology, abnormal embryo development, abnormal induced retina neovascularization, abnormal lymphopoiesis, abnormal pericardial cavity morphology, abnormal placenta vasculature, abnormal retina vasculature morphology, abnormal sinus venosus morphology, abnormal thymus cell ratio, abnormal umbilical artery morphology, abnormal vascular branching morphogenesis, abnormal vascular development, abnormal vascular regression, abnormal vascular smooth muscle morphology, abnormal vein development, abnormal visceral yolk sac morphology, abnormal vitelline vascular remodeling, abnormal vitelline vasculature morphology, absent CD4-positive, alpha beta T cells, absent vitelline blood vessels, blood vessel atresia, decreased CD4-positive, alpha beta T cell number, decreased double-positive T cell number, decreased thymocyte number, embryo tissue necrosis, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, immune system phenotype, increased immature B cell number, no abnormal phenotype detected, pericardial edema, poor circulation, prenatal lethality, incomplete penetrance, preweaning lethality, complete penetrance, trabecula carnea hypoplasia [+]
View all ortholog results at Monarch