chrd.1 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (720)

XB-GENEPAGE-480637

Gene Symbol: chrd.1 Gene Name: chordin, gene 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
wholly ventralized embryo (3 sources), abnormally posterioralized embryo (1 source), abnormally ventralized embryo (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: chrd.1 manipulated (6 sources), chrd.1 assayed (75 sources)
Computed annotations: chrd.1 manipulated (1 source), chrd.1 assayed (50 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + chrd.1 MO (3 sources), Xtr Wt + chrd.1 CRISPR (3 sources), Xtr Wt + rspo2 CRISPR + chrd.1 CRISPR (2 sources), Xla Wt + chrd MO + nog MO (1 source), Xla Wt + chrd MO + nog MO (1 source), Xla Wt + chrd.1 + animal cap explant (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (78 sources): abnormal artery morphology, abnormal brachiocephalic trunk morphology, abnormal brain development, abnormal cardiovascular development, abnormal common carotid artery morphology, abnormal cranial ganglia morphology, abnormal ear development, abnormal ear position, abnormal embryonic tissue morphology, abnormal extraembryonic tissue morphology, abnormal laryngeal cartilage morphology, abnormal mandible morphology, abnormal mesoderm development, abnormal miniature excitatory postsynaptic currents, abnormal neural crest cell migration, abnormal neural plate morphology, abnormal oropharynx morphology, abnormal pharyngeal arch artery morphology, abnormal pharyngeal pouch morphology, abnormal response to novel object, abnormal secondary palate development, abnormal spatial learning, abnormal thoracic vertebrae morphology, abnormal trigeminal ganglion morphology, abnormal tympanic ring morphology, abnormal vertebral arch development, abnormal vestibulocochlear ganglion morphology, absent arcus anterior, absent esophagus, absent mandible, absent mandibular angle, absent mandibular condyloid process, absent mandibular coronoid process, absent mesoderm, absent nodose ganglion, absent notochord, absent parathyroid glands, absent petrosal ganglion, absent pharyngeal arches, absent pulmonary trunk, absent somites, absent temporal bone squamous part, cricoid cartilage hypoplasia, decreased body size, decreased embryo size, decreased exploration in new environment, decreased tympanic ring size, embryonic lethality between somite formation and embryo turning, complete penetrance, enhanced long term potentiation, enhanced paired-pulse facilitation, enlarged allantois, fusion of basioccipital and basisphenoid bone, hyoid bone hypoplasia, increased neurotransmitter release, increased vasodilation, lethality throughout fetal growth and development, incomplete penetrance, nervous system phenotype, no abnormal phenotype detected, palatal shelves fail to meet at midline, perinatal lethality, complete penetrance, perinatal lethality, incomplete penetrance, presphenoid bone hypoplasia, renal/urinary system phenotype, reproductive system phenotype, retroesophageal right subclavian artery, short mandible, short zygomatic arch, small geniculate ganglion, small mandible, small nodose ganglion, small otic capsule, small otic vesicle, small petrosal ganglion, small pharynx, small temporal bone, small trachea, small vertebral body, thyroid cartilage hypoplasia [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (78 sources): abnormal artery morphology, abnormal brachiocephalic trunk morphology, abnormal brain development, abnormal cardiovascular development, abnormal common carotid artery morphology, abnormal cranial ganglia morphology, abnormal ear development, abnormal ear position, abnormal embryonic tissue morphology, abnormal extraembryonic tissue morphology, [+]