| Monarch Ortholog Phenotypes
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Human (16 sources):
Abnormality of neutrophils,
Arrhythmia,
Atrial septal defect,
Congestive heart failure,
Dilated cardiomyopathy,
EMG abnormality,
Elevated circulating creatine kinase concentration,
Hypertrophic cardiomyopathy,
Left ventricular hypertrophy,
Left ventricular noncompaction,
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Mouse (27 sources):
abnormal craniofacial morphology,
abnormal erythrocyte cell number,
abnormal hindbrain development,
abnormal midbrain development,
abnormal myocardial fiber morphology,
abnormal myocardial fiber physiology,
abnormal sarcomere morphology,
abnormal visceral yolk sac morphology,
cardiac fibrosis,
decreased QRS amplitude,
decreased body size,
decreased cardiac muscle contractility,
delayed heart development,
dilated heart left ventricle,
disorganized myocardium,
increased cardiomyocyte apoptosis,
increased erythrocyte cell number,
increased heart weight,
increased prepulse inhibition,
lethality throughout fetal growth and development, incomplete penetrance,
muscle degeneration,
myocardial fiber degeneration,
myocardial fiber disarray,
no abnormal phenotype detected,
postnatal lethality, complete penetrance,
premature death,
preweaning lethality, complete penetrance
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.