hspa5 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-480059

Gene Symbol: hspa5 Gene Name: heat shock protein family A (Hsp70) member 5

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal development of optic tectum (1 source), abnormally decreased number of neuron (1 source), abnormally increased number of neural progenitor cell (1 source), decreased cell population proliferation in neural progenitor cell (1 source), decreased cell population proliferation in optic tectum (1 source), decreased neuron differentiation in optic tectum (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: hspa5 assayed (1 source)
Computed annotations: hspa5 assayed (3 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + hspa5 MO (7 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (41 sources): abnormal alveolar lamellar body morphology, abnormal axon extension, abnormal axon fasciculation, abnormal axon morphology, abnormal blastocyst morphology, abnormal brain internal capsule morphology, abnormal brain white matter morphology, abnormal cerebral cortex morphology, abnormal circulating cholesterol level, abnormal cortical intermediate zone morphology, abnormal inner cell mass apoptosis, abnormal neuron differentiation, abnormal neuron proliferation, abnormal pulmonary alveolus epithelial cell morphology, abnormal renal tubule morphology, abnormal stratification in cerebral cortex, abnormal surfactant secretion, abnormal telencephalon morphology, abnormal type II pneumocyte morphology, absent inner cell mass proliferation, decreased body size, decreased fetal size, decreased surfactant secretion, dilated renal tubules, embryonic lethality at implantation, complete penetrance, embryonic lethality prior to organogenesis, embryonic lethality prior to tooth bud stage, empty decidua capsularis, failure of blastocyst to hatch from the zona pellucida, forebrain hypoplasia, hematoma, increased lean body mass, increased susceptibility to injury, neonatal lethality, complete penetrance, nervous system phenotype, no abnormal phenotype detected, preweaning lethality, complete penetrance, pulmonary alveolar hemorrhage, reproductive system phenotype, small kidney, small olfactory bulb [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (41 sources): abnormal alveolar lamellar body morphology, abnormal axon extension, abnormal axon fasciculation, abnormal axon morphology, abnormal blastocyst morphology, abnormal brain internal capsule morphology, abnormal brain white matter morphology, abnormal cerebral cortex morphology, abnormal circulating cholesterol level, abnormal cortical intermediate zone morphology, [+]