| Monarch Ortholog Phenotypes
|
Human (27 sources):
Abnormality of neutrophils,
Ascites,
Atrioventricular block,
Cardiac arrest,
Cardiomegaly,
Chest pain,
Dilated cardiomyopathy,
Dyspnea,
EMG abnormality,
Elevated circulating creatine kinase concentration,
Hepatomegaly,
Hypertrophic cardiomyopathy,
Left bundle branch block,
Left ventricular noncompaction,
Lipoatrophy,
Myopathy,
Palmoplantar keratoderma,
Pericardial effusion,
Pulmonary edema,
Right bundle branch block,
Sensorineural hearing impairment,
Stroke,
Syncope,
Transient ischemic attack,
Ventricular fibrillation,
Ventricular hypertrophy,
Ventricular septal hypertrophy
[+]
|
Mouse (31 sources):
abnormal M line morphology,
abnormal Z line morphology,
abnormal cardiac muscle contractility,
abnormal cardiac muscle relaxation,
abnormal heart echocardiography feature,
abnormal myocardial fiber morphology,
abnormal myocardial fiber physiology,
abnormal response to new environment,
abnormal sarcomere morphology,
abnormal ventricle papillary muscle morphology,
cardiac fibrosis,
cardiac hypertrophy,
cardiac interstitial fibrosis,
cardiovascular system phenotype,
decreased cardiac muscle contractility,
decreased cardiac stroke volume,
decreased circulating amylase level,
decreased ventricle muscle contractility,
dilated heart left atrium,
dilated heart left ventricle,
disorganized myocardium,
dystrophic cardiac calcinosis,
enlarged myocardial fiber,
impaired exercise endurance,
increased cardiac muscle contractility,
increased heart weight,
increased response of heart to induced stress,
increased sensitivity to induced morbidity/mortality,
myocardial fiber degeneration,
myocardial fiber disarray,
thick ventricular wall
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.