| Monarch Ortholog Phenotypes
|
|
Human (10 sources):
Abnormality of the urinary system,
Anuria,
Hypotension,
Microcephaly,
Oligohydramnios,
Potter facies,
Pulmonary hypoplasia,
Renotubular dysgenesis,
Respiratory insufficiency,
Widely patent fontanelles and sutures
|
Mouse (49 sources):
abnormal adipose tissue development,
abnormal amygdala morphology,
abnormal blood homeostasis,
abnormal erythrocyte cell number,
abnormal heart rate,
abnormal hematocrit,
abnormal hemoglobin content,
abnormal impulse conducting system conduction,
abnormal juxtaglomerular apparatus morphology,
abnormal kidney blood vessel morphology,
abnormal kidney interlobular artery morphology,
abnormal kidney interstitium morphology,
abnormal kidney morphology,
abnormal physiological response to xenobiotic,
abnormal renal water reabsorption,
abnormal response/metabolism to endogenous compounds,
abnormal systemic arterial blood pressure,
adipose tissue phenotype,
cardiac fibrosis,
cardiac interstitial fibrosis,
cardiovascular system phenotype,
decreased circulating angiotensin II level,
decreased heart weight,
decreased mean systemic arterial blood pressure,
decreased physiological sensitivity to xenobiotic,
decreased renal glomerular filtration rate,
decreased susceptibility to injury,
decreased systemic arterial blood pressure,
decreased systemic arterial systolic blood pressure,
decreased urine creatinine level,
decreased white fat cell number,
enlarged heart atrium,
growth/size/body region phenotype,
heart hyperplasia,
high mean erythrocyte cell number,
homeostasis/metabolism phenotype,
increased fluid intake,
increased heart weight,
increased renin activity,
increased spleen weight,
increased systemic arterial blood pressure,
increased systemic arterial systolic blood pressure,
increased urine osmolality,
increased white fat cell size,
juxtaglomerular cell hyperplasia,
no abnormal phenotype detected,
perinatal lethality, incomplete penetrance,
prolonged QRS complex duration,
renal/urinary system phenotype
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.