| Monarch Ortholog Phenotypes
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Human (61 sources):
Abnormal cardiovascular system morphology,
Absent nasal septal cartilage,
Adrenal hypoplasia,
Agenesis of corpus callosum,
Ambiguous genitalia,
Anterior pituitary agenesis,
Anteverted nares,
Aplasia of the nose,
Aplasia/Hypoplasia of the corpus callosum,
Asthma,
Bifid uvula,
Cerebellar hypoplasia,
Cerebral cortical atrophy,
Choanal atresia,
Cleft palate,
Constipation,
Cyclopia,
Diabetes insipidus,
Duodenal atresia,
EEG abnormality,
EMG: myopathic abnormalities,
Generalized hypotonia,
Global developmental delay,
Hemangioma,
Hemiparesis,
Holoprosencephaly,
Hypoplasia of penis,
Hypotelorism,
Hypothyroidism,
Hypotonia,
Intellectual disability,
Intrauterine growth retardation,
Iris coloboma,
Malar flattening,
Maternal diabetes,
Median cleft lip and palate,
Microcephaly,
Microphthalmia,
Midface retrusion,
Midnasal stenosis,
Narrow nasal bridge,
Orofacial cleft,
Panhypopituitarism,
Porencephalic cyst,
Premature birth,
Proboscis,
Renal agenesis,
Schizencephaly,
Scoliosis,
Seizure,
Short nose,
Short philtrum,
Short stature,
Single ventricle,
Solitary median maxillary central incisor,
Spastic tetraplegia,
Spasticity,
Strabismus,
Submucous cleft hard palate,
Tented upper lip vermilion,
Tetralogy of Fallot
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Mouse (17 sources):
abnormal craniofacial morphology,
abnormal cranium morphology,
abnormal forebrain development,
abnormal lens development,
abnormal lens fiber morphology,
abnormal lens induction,
abnormal lens vesicle development,
abnormal optic vesicle formation,
abnormal rostral-caudal axis patterning,
absent embryonic telencephalon,
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.