| Monarch Ortholog Phenotypes
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Human (24 sources):
Abnormal hair quantity,
Abnormal neck blood vessel morphology,
Abnormality of the lymph nodes,
Bifid epiglottis,
Bone pain,
Choanal atresia,
Chronic lung disease,
Chronic noninfectious lymphadenopathy,
Cleft palate,
Colon cancer,
Congenital hypothyroidism,
Follicular thyroid carcinoma,
Goiter,
Intellectual disability,
Neoplasm of head and neck,
Nodular goiter,
Pain,
Papillary renal cell carcinoma,
Papillary thyroid carcinoma,
Polyhydramnios,
Recurrent fractures,
Retrognathia,
Spinal cord compression,
Thyroid agenesis
[+]
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Mouse (8 sources):
abnormal coat appearance,
abnormal hair follicle orientation,
abnormal thyroid gland development,
decreased circulating levels of thyroid hormone,
increased circulating thyroid-stimulating hormone level,
increased curvature of hairs,
palatal shelves fail to meet at midline,
postnatal lethality, complete penetrance
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.