tbx3 Phenotypes

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Phenotypes

Gene Literature (45)

Nucleotides (133)

Interactants (652)

XB-GENEPAGE-1018230

Gene Symbol: tbx3 Gene Name: T-box 3

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal gastrulation (2 sources), abnormal axis elongation (1 source), abnormal bending of tail (1 source), abnormally delayed closure of blastopore (1 source), abnormal tail morphology (1 source), absent head (1 source), absent tail (1 source), decreased length of anterior-posterior axis (1 source), decreased size of the head (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: tbx3 assayed (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + tbx3 MO (2 sources), Xtr Wt + tbx3 MO (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (58 sources): Abnormal clavicle morphology, Abnormal finger morphology, Abnormal fingernail morphology, Abnormality of temperature regulation, Abnormality of the uterus, Abnormality of the wrist, Abnormal morphology of the radius, Absent axillary hair, Absent hand, Absent radius, Anal atresia, Anal stenosis, Anterior pituitary hypoplasia, Aplasia/Hypoplasia of the ulna, Aplasia of the pectoralis major muscle, Aplasia of the ulna, Arrhythmia, Axillary apocrine gland hypoplasia, Breast aplasia, Breast hypoplasia, Camptodactyly of finger, Cryptorchidism, Decreased fertility, Deformed radius, Delayed puberty, Ectopic anus, Ectopic posterior pituitary, Gastroschisis, Hypodontia, Hypoplasia of penis, Hypoplasia of the radius, Hypoplasia of the ulna, Hypoplastic nipples, Hypoplastic scapulae, Hypoplastic toenails, Imperforate hymen, Inverted nipples, Laryngomalacia, Micropenis, Obesity, obsolete Abnormality of the humerus, obsolete Abnormality of the metacarpal bones, Pectus carinatum, Postaxial hand polydactyly, Pyloric stenosis, Renal hypoplasia, Shawl scrotum, Short 4th toe, Short 5th toe, Short clavicles, Short distal phalanx of finger, Short humerus, Short stature, Sparse axillary hair, Sparse lateral eyebrow, Sprengel anomaly, Subglottic stenosis, Ventricular septal defect [+]
Mouse (52 sources): abnormal cardiovascular development, abnormal clitoris morphology, abnormal embryonic autopod plate morphology, abnormal female reproductive system morphology, abnormal fetal atrioventricular canal morphology, abnormal forelimb morphology, abnormal heart development, abnormal heart looping, abnormal hindlimb morphology, abnormal hindlimb zeugopod morphology, abnormal impulse conducting system conduction, abnormal limb development, abnormal limb morphology, abnormal mammary gland bud morphology, abnormal mammary gland development, abnormal mammary gland embryonic development, abnormal palatal shelf fusion at midline, abnormal P wave, abnormal QRS complex, abnormal sinoatrial node morphology, abnormal sinus arrhythmia, abnormal vagina orifice morphology, abnormal visceral yolk sac endoderm morphology, abnormal vitelline vasculature morphology, absent PR interval, absent P wave, absent tarsus bones, absent vitelline blood vessels, decreased body size, delayed heart looping, embryonic lethality, complete penetrance, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, embryonic lethality, incomplete penetrance, embryo phenotype, failure of heart looping, increased cardiac muscle contractility, increased heart rate variability, lethality throughout fetal growth and development, complete penetrance, no abnormal phenotype detected, pale yolk sac, pericardial edema, postnatal lethality, incomplete penetrance, premature death, prenatal lethality, incomplete penetrance, preweaning lethality, incomplete penetrance, prolonged QRS complex duration, reduced female fertility, reduced male fertility, small hindlimb buds, small liver, thin apical ectodermal ridge [+]
View all ortholog results at Monarch