dvl2 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (349)

XB-GENEPAGE-1017460

Gene Symbol: dvl2 Gene Name: dishevelled segment polarity protein 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormally increased number of multiciliated cell (2 sources), absent epidermis outer layer (2 sources), absent multiciliated cell (2 sources), decreased length of anterior-posterior axis (2 sources), increased thickness of the ectoderm (2 sources), abnormal bending of anterior-posterior axis (1 source), abnormal cell migration (1 source), abnormal development of hindgut (1 source), abnormal gastrulation (1 source), abnormal incomplete closing of the neural fold (1 source), abnormal incomplete closing of the neural tube (1 source), abnormally decreased length of hindgut (1 source), abnormal neural tube closure (1 source), abnormal neural tube morphology (1 source), abnormal retina (1 source), increased size of the foregut (1 source), obsolete duplicated anterior-posterior axis (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormally increased number of multiciliated cell (2 sources), absent epidermis outer layer (2 sources), absent multiciliated cell (2 sources), decreased length of anterior-posterior axis (2 sources), increased thickness of the ectoderm (2 sources), abnormal bending of anterior-posterior axis (1 source), abnormal cell migration (1 source), abnormal development of hindgut (1 source), abnormal gastrulation (1 source), abnormal incomplete closing of the neural fold (1 source), abnormal incomplete closing of the neural tube (1 source), abnormally decreased length of hindgut (1 source), abnormal neural tube closure (1 source), abnormal neural tube morphology (1 source), abnormal retina (1 source), increased size of the foregut (1 source), obsolete duplicated anterior-posterior axis (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: dvl2 manipulated (6 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + dndvl2 (3 sources), Xla Wt + dndvl2-GFP (3 sources), Xla Wt + dndvl2-GFP (2 sources), Xla Wt + dndvl2-GFP + sfrp5 MO (2 sources), Xla Wt + dndvl2 (1 source), Xla Wt + dndvl2 (1 source), Xla Wt + dndvl2 + cdh2 MO (1 source), Xla Wt + dvl2 (1 source), Xla Wt + dvl2del_1236-2208 (1 source), Xla Wt + dvl2del_1236-2208 (1 source), Xla Wt + dvl2 MO (1 source), Xla Wt + dvl2 MO + dvl3 MO (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xla Wt + dndvl2 (3 sources), Xla Wt + dndvl2-GFP (3 sources), Xla Wt + dndvl2-GFP (2 sources), Xla Wt + dndvl2-GFP + sfrp5 MO (2 sources), Xla Wt + dndvl2 (1 source), Xla Wt + dndvl2 (1 source), Xla Wt + dndvl2 + cdh2 MO (1 source), Xla Wt + dvl2 (1 source), Xla Wt + dvl2del_1236-2208 (1 source), Xla Wt + dvl2del_1236-2208 (1 source), Xla Wt + dvl2 MO (1 source), Xla Wt + dvl2 MO + dvl3 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (9 sources): abnormal somite development, abnormal thoracic vertebrae morphology, abnormal xiphoid process morphology, hearing/vestibular/ear phenotype, kinked tail, open neural tube, perinatal lethality, incomplete penetrance, short hair, vestigial tail