klf4 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-1015048

Gene Symbol: klf4 Gene Name: KLF transcription factor 4

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: klf4 assayed (1 source)
Computed annotations: klf4 assayed (14 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (52 sources): abnormal Bowman membrane morphology, abnormal Sertoli cell development, abnormal colon goblet cell morphology, abnormal cornea anterior stroma morphology, abnormal corneal stroma morphology, abnormal epidermis stratum corneum morphology, abnormal epidermis stratum granulosum morphology, abnormal esophageal epithelium morphology, abnormal gastric chief cell morphology, abnormal gastric gland morphology, abnormal gastric parietal cell morphology, abnormal gastric surface mucous cell morphology, abnormal intestinal epithelium morphology, abnormal intestinal goblet cell morphology, abnormal keratinocyte differentiation, abnormal keratinocyte morphology, abnormal lens fiber morphology, abnormal mucous neck cell morphology, abnormal seminiferous tubule epithelium morphology, abnormal seminiferous tubule size, abnormal stomach epithelium morphology, abnormal suckling behavior, abnormal testes secretion, abnormal tongue epithelium morphology, abnormal tongue squamous epithelium morphology, absent conjunctiva goblet cells, acoria, decreased Ly6C low monocyte number, decreased corneal epithelium thickness, decreased grip strength, ectopic Paneth cells, focal ventral hair loss, impaired skin barrier function, impaired wound healing, increased Paneth cell number, increased cornea fragility, increased corneal stroma thickness, increased hair follicle cell proliferation, increased hair follicle number, increased incidence of tumors by chemical induction, increased keratinocyte adhesion, increased keratinocyte migration, increased keratinocyte proliferation, iris hyperplasia, neonatal lethality, complete penetrance, no abnormal phenotype detected, preneoplasia, reproductive system phenotype, skin lesions, small pupils, thick epidermis suprabasal layer, vacuolated lens [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (52 sources): abnormal Bowman membrane morphology, abnormal Sertoli cell development, abnormal colon goblet cell morphology, abnormal cornea anterior stroma morphology, abnormal corneal stroma morphology, abnormal epidermis stratum corneum morphology, abnormal epidermis stratum granulosum morphology, abnormal esophageal epithelium morphology, abnormal gastric chief cell morphology, abnormal gastric gland morphology, [+]