ift80 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-1014835

Gene Symbol: ift80 Gene Name: intraflagellar transport 80

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
edematous embryo (3 sources), abnormal cartilage tissue morphology in the hindlimb (1 source), abnormal cilium morphology in the multiciliated epidermal cell (1 source), abnormal forelimb digit morphology (1 source), abnormal hindlimb digit morphology (1 source), abnormal kidney morphology (1 source), abnormal pronephric kidney (1 source), abnormally decreased number of cilium in the multiciliated cell (1 source), abnormally increased number of digit (1 source), decreased length of forelimb (1 source), decreased length of hindlimb (1 source), decreased length of hindlimb digit (1 source), decreased size of the cilium in the multiciliated cell (1 source), decreased size of the forelimb digit (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

edematous embryo (3 sources), abnormal cartilage tissue morphology in the hindlimb (1 source), abnormal cilium morphology in the multiciliated epidermal cell (1 source), abnormal forelimb digit morphology (1 source), abnormal hindlimb digit morphology (1 source), abnormal kidney morphology (1 source), abnormal pronephric kidney (1 source), abnormally decreased number of cilium in the multiciliated cell (1 source), abnormally increased number of digit (1 source), decreased length of forelimb (1 source), decreased length of hindlimb (1 source), decreased length of hindlimb digit (1 source), decreased size of the cilium in the multiciliated cell (1 source), decreased size of the forelimb digit (1 source)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
ciliopathy (9AP sources), kidney disease (9AP sources), polydactyly (5AP sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + ift80 CRISPR (6 sources), Xla Wt + ift80 CRISPR (1 source), Xtr Wt + ift80 CRISPR (1 source), Xtr Wt + ift80 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (109 sources): Abdominal distention, Abnormal cardiovascular system morphology, Abnormal clavicle morphology, Abnormal pelvis bone ossification, Abnormal rib morphology, Abnormal sternum morphology, Abnormality of pelvic girdle bone morphology, Abnormality of retinal pigmentation, Abnormality of the liver, Abnormality of the metaphysis, Abnormality of the pinna, Absent or minimally ossified vertebral bodies, Agenesis of corpus callosum, Ambiguous genitalia, Anal atresia, Anencephaly, Aplasia/Hypoplasia of the lungs, Ascites, Atelectasis, Bifid epiglottis, Bifid tongue, Bowing of the arm, Bowing of the legs, Brachydactyly, Broad foot, Broad palm, Cataract, Cerebellar hypoplasia, Cleft upper lip, Cone-shaped epiphysis, Congenital hepatic fibrosis, Cryptorchidism, Cystic renal dysplasia, Dandy-Walker malformation, Depressed nasal bridge, Disproportionate short-limb short stature, Ectopic anus, Edema, Epicanthus, Esophageal atresia, Feeding difficulties in infancy, Flat face, Frontal bossing, Hamartoma of tongue, Hepatomegaly, High forehead, Holoprosencephaly, Horizontal ribs, Hydrocephalus, Hydronephrosis, Hydrops fetalis, Hypertelorism, Hypoplasia of penis, Hypoplastic nipples, Hypoplastic scapulae, Intestinal malrotation, Intrauterine growth retardation, Lethal skeletal dysplasia, Lobulated tongue, Long philtrum, Low-set ears, Macrocephaly, Median cleft lip and palate, Median cleft upper lip, Mesomelia, Micrognathia, Micromelia, Narrow chest, Natal tooth, Nephronophthisis, Nephropathy, Omphalocele, Oral ulcer, Patent ductus arteriosus, Patent foramen ovale, Periportal fibrosis, Polyhydramnios, Postaxial foot polydactyly, Postaxial hand polydactyly, Posteriorly rotated ears, Preaxial hand polydactyly, Protuberant abdomen, Pulmonary hypoplasia, Renal cyst, Renal hypoplasia, Renal insufficiency, Respiratory insufficiency, Rhizomelia, Short finger, Short foot, Short long bone, Short metacarpal, Short neck, Short palm, Short ribs, Short stature, Short thorax, Short toe, Skeletal dysplasia, Splenomegaly, Tessier cleft, Thoracic dysplasia, Toe syndactyly, Urethrovaginal fistula, Uterus didelphys, Ventricular septal defect, Ventriculomegaly, Wide intermamillary distance, Wide nose [+]
Mouse (16 sources): abnormal circulating free fatty acids level, abnormal cranium morphology, abnormal long bone hypertrophic chondrocyte zone, abnormal motile cilium morphology, abnormal thoracic cage shape, decreased birth body size, decreased circulating free fatty acids level, decreased width of hypertrophic chondrocyte zone, disorganized long bone epiphyseal plate, growth/size/body region phenotype, lethality, incomplete penetrance, perinatal lethality, incomplete penetrance, preweaning lethality, incomplete penetrance, renal/urinary system phenotype, small cranium, vision/eye phenotype [+]
View all ortholog results at Monarch