bcl3 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (1)

XB-GENEPAGE-995146

Gene Symbol: bcl3 Gene Name: BCL3, transcription coactivator

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: bcl3 assayed (4 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (60 sources): abnormal B-2 B cell morphology, abnormal Peyer's patch T cell area morphology, abnormal Peyer's patch follicle morphology, abnormal Peyer's patch germinal center morphology, abnormal Peyer's patch morphology, abnormal class switch recombination, abnormal cytotoxic T cell physiology, abnormal dendritic cell number, abnormal follicular B cell morphology, abnormal follicular dendritic cell morphology, abnormal humoral immune response, abnormal innate immunity, abnormal lymph node B cell domain morphology, abnormal macrophage physiology, abnormal metallophilic macrophage morphology, abnormal myeloid dendritic cell morphology, abnormal nitric oxide homeostasis, abnormal snout morphology, abnormal spleen B cell follicle morphology, abnormal spleen marginal zone macrophage morphology, abnormal spleen weight, abnormal transitional stage T3 B cell morphology, absent marginal zone B cells, absent spleen germinal center, decreased B cell apoptosis, decreased B cell proliferation, decreased B-1 B cell number, decreased B-1a cell number, decreased B-1b cell number, decreased CD4-positive, alpha beta T cell number, decreased IgG1 level, decreased IgG2a level, decreased IgG2b level, decreased IgG3 level, decreased Peyer's patch number, decreased central memory CD8 positive, alpha-beta T cell number, decreased follicular B cell number, decreased immature B cell number, decreased interferon-gamma secretion, decreased interleukin-12 secretion, decreased macrophage cell number, decreased marginal zone B cell number, decreased spleen germinal center size, decreased transitional stage T1 B cell number, decreased transitional stage T2 B cell number, immune system phenotype, increased B cell proliferation, increased B-1 B cell number, increased CD8-positive, alpha-beta T cell number, increased CD8-positive, alpha-beta memory T cell number, increased central memory CD4-positive, alpha-beta T cell number, increased macrophage cell number, increased marginal zone B cell number, increased neutrophil cell number, increased plasmacytoid dendritic cell number, increased sensitivity to induced morbidity/mortality, increased spleen weight, increased susceptibility to parasitic infection, intermingled spleen red and white pulp, small Peyer's patches [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (60 sources): abnormal B-2 B cell morphology, abnormal Peyer's patch T cell area morphology, abnormal Peyer's patch follicle morphology, abnormal Peyer's patch germinal center morphology, abnormal Peyer's patch morphology, abnormal class switch recombination, abnormal cytotoxic T cell physiology, abnormal dendritic cell number, abnormal follicular B cell morphology, abnormal follicular dendritic cell morphology, [+]