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XB-GENEPAGE-991125
cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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abnormal gastrulation (2 sources), abnormal blastopore morphology (1 source) |
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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Manual annotations: cacna1c manipulated (2 sources) |
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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Xtr Wt + cacna1c CRISPR + kcnh6 MO (2 sources) |
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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Human (40 sources): Atrial fibrillation, Autism, Bradycardia, Bronchitis, Cardiac arrest, Cardiomegaly, Cutaneous syndactyly, Depressed nasal bridge, First degree atrioventricular block, Generalized hypotonia, [+] |
Mouse (44 sources): abnormal CNS synaptic transmission, abnormal calcium ion homeostasis, abnormal cardiac muscle contractility, abnormal craniofacial morphology, abnormal embryonic tissue morphology, abnormal fetal cardiomyocyte physiology, abnormal learning/memory/conditioning, abnormal long term spatial reference memory, abnormal motor capabilities/coordination/movement, abnormal muscle electrophysiology, [+] |
View all ortholog results at Monarch |