Monarch Ortholog Phenotypes
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Mouse (29 sources):
abnormal CD4-positive, alpha beta T cell number,
abnormal CD8-positive, alpha-beta T cell number,
abnormal abdominal lymph node morphology,
abnormal bone marrow cell number,
abnormal definitive hematopoiesis,
abnormal erythropoiesis,
abnormal myelopoiesis,
abnormal spleen B cell follicle morphology,
abnormal spleen marginal zone morphology,
abnormal spleen red pulp morphology,
abnormal thymus corticomedullary boundary morphology,
abnormal thymus morphology,
decreased body size,
decreased locomotor activity,
decreased macrophage cell number,
decreased single-positive T cell number,
delayed heart development,
distended pericardium,
embryonic growth retardation,
embryonic lethality during organogenesis, complete penetrance,
increased CD8-positive, alpha-beta T cell number,
increased fibroblast apoptosis,
increased granulocyte number,
increased neutrophil cell number,
increased thymocyte apoptosis,
pericardial edema,
premature death,
preweaning lethality, complete penetrance,
thin myocardium
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