Monarch Ortholog Phenotypes
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Mouse (40 sources):
abnormal CD4-positive, alpha beta T cell morphology,
abnormal CD4-positive, alpha-beta T cell physiology,
abnormal CD4-positive, alpha-beta intraepithelial T cell morphology,
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology,
abnormal Peyer's patch T cell area morphology,
abnormal Peyer's patch follicle morphology,
abnormal Peyer's patch germinal center morphology,
abnormal Peyer's patch morphology,
abnormal alpha-beta intraepithelial T cell morphology,
abnormal choroid plexus morphology,
abnormal dendritic cell physiology,
abnormal effector T cell morphology,
abnormal follicular dendritic cell antigen presentation,
abnormal follicular dendritic cell physiology,
abnormal gut-associated lymphoid tissue morphology,
abnormal intraepithelial T cell number,
abnormal macrophage physiology,
abnormal myeloid dendritic cell morphology,
abnormal peritoneal macrophage morphology,
decreased CD4-positive, alpha beta T cell number,
decreased IgG3 level,
decreased Peyer's patch number,
decreased interleukin-10 secretion,
decreased interleukin-12 secretion,
decreased interleukin-4 secretion,
decreased interleukin-5 secretion,
decreased macrophage cytokine production,
decreased macrophage nitric oxide production,
decreased susceptibility to bacterial infection,
decreased susceptibility to experimental autoimmune encephalomyelitis,
decreased susceptibility to type I hypersensitivity reaction,
decreased tumor necrosis factor secretion,
impaired eosinophil recruitment,
increased B-1 B cell number,
increased T cell proliferation,
increased activated T cell number,
increased double-positive T cell number,
increased interferon-gamma secretion,
increased susceptibility to Riboviria infection,
no abnormal phenotype detected
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