| Monarch Ortholog Phenotypes
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Human (5 sources):
Cardiomegaly,
Hydrops fetalis,
Mitral regurgitation,
Prolonged QT interval,
Tricuspid regurgitation
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Mouse (22 sources):
abnormal anxiety-related response,
abnormal heart layer morphology,
abnormal heart left ventricle pressure,
abnormal intercalated disk morphology,
abnormal locomotor activation,
abnormal myocardial fiber morphology,
abnormal myocardium layer morphology,
cardiac hypertrophy,
decreased cardiac muscle contractility,
decreased cardiac output,
decreased cardiac stroke volume,
decreased eosinophil cell number,
decreased prepulse inhibition,
decreased systemic arterial systolic blood pressure,
decreased ventricle muscle contractility,
dilated heart left ventricle,
increased heart left ventricle size,
increased heart weight,
myocardium hypertrophy,
preweaning lethality, incomplete penetrance,
thick interventricular septum,
thick ventricular wall
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.