lif Phenotypes

Summary

Expression

Phenotypes

Gene Literature (33)

XB-GENEPAGE-984970

Gene Symbol: lif Gene Name: LIF, interleukin 6 family cytokine

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal anterior/posterior axis specification (6 sources), abnormally ventralized embryo (6 sources), decreased size of the head (4 sources), abnormal protein phosphorylation (3 sources), increased cell population proliferation in ventral region (2 sources), abnormal epidermis morphology (1 source), absent head (1 source), decreased width of the neural plate (1 source), increased cell population proliferation in antero-ventral region (1 source), increased cell population proliferation in epidermis (1 source), increased cell population proliferation in posterior region (1 source), increased cell population proliferation in postero-dorsal region (1 source), increased cell population proliferation in trunk (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal anterior/posterior axis specification (6 sources), abnormally ventralized embryo (6 sources), decreased size of the head (4 sources), abnormal protein phosphorylation (3 sources), increased cell population proliferation in ventral region (2 sources), abnormal epidermis morphology (1 source), absent head (1 source), decreased width of the neural plate (1 source), increased cell population proliferation in antero-ventral region (1 source), increased cell population proliferation in epidermis (1 source), increased cell population proliferation in posterior region (1 source), increased cell population proliferation in postero-dorsal region (1 source), increased cell population proliferation in trunk (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: lif manipulated (19 sources)
Computed annotations: lif assayed (26 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
cancer (7AP sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + lif (33 sources), Xla Wt + lif (2 sources), Xla Wt + lif (1 source), Xla Wt + lif (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (49 sources): abnormal CNS glial cell morphology, abnormal astrocyte morphology, abnormal brain vasculature morphology, abnormal embryo apposition, abnormal embryo attachment, abnormal glial cell morphology, abnormal hepatocyte morphology, abnormal induced retina neovascularization, abnormal involution of the mammary gland, abnormal mammary gland alveolus morphology, abnormal mammary gland duct morphology, abnormal mammary gland growth during pregnancy, abnormal mammary gland physiology, abnormal osteoclast differentiation, abnormal osteoclast morphology, abnormal osteoclast physiology, abnormal pilomotor reflex, abnormal retina vasculature morphology, abnormal uterine receptivity, abnormal uterus morphology, decreased T cell proliferation, decreased body size, decreased bone volume, decreased common myeloid progenitor cell number, decreased hematopoietic stem cell number, decreased interleukin-10 secretion, decreased motor neuron number, decreased susceptibility to injury, failure of embryo implantation, hematopoietic system phenotype, hypoxia, increased acute inflammation, increased circulating alanine transaminase level, increased circulating aspartate transaminase level, increased circulating insulin-like growth factor I level, increased circulating interleukin-1 beta level, increased circulating interleukin-6 level, increased circulating serum amyloid protein level, increased circulating tumor necrosis factor level, increased osteoclast cell number, increased susceptibility to bacterial infection induced morbidity/mortality, increased susceptibility to endotoxin shock, increased susceptibility to weight loss, increased uterine NK cell number, increased vascular endothelial cell proliferation, liver hemorrhage, liver vascular congestion, nervous system phenotype, postnatal lethality, incomplete penetrance [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (49 sources): abnormal CNS glial cell morphology, abnormal astrocyte morphology, abnormal brain vasculature morphology, abnormal embryo apposition, abnormal embryo attachment, abnormal glial cell morphology, abnormal hepatocyte morphology, abnormal induced retina neovascularization, abnormal involution of the mammary gland, abnormal mammary gland alveolus morphology, [+]