| Monarch Ortholog Phenotypes
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Human (28 sources):
Abnormal bleeding,
Arthrogryposis multiplex congenita,
Atrial septal defect,
Cholestatic liver disease,
Conjugated hyperbilirubinemia,
Dehydration,
Elevated circulating hepatic transaminase concentration,
Failure to thrive,
Generalized hypotonia,
Giant cell hepatitis,
Global developmental delay,
Hip dysplasia,
Hypotonia,
Ichthyosis,
Jaundice,
Lissencephaly,
Low-set ears,
Metabolic acidosis,
Microcephaly,
Micrognathia,
Nephrocalcinosis,
Nephrogenic diabetes insipidus,
Nephropathy,
Renal tubular acidosis,
Right ventricular hypertrophy,
Sloping forehead,
Talipes calcaneovalgus,
Ventricular septal defect
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Mouse (13 sources):
abnormal megakaryocyte morphology,
abnormal placenta morphology,
abnormal tendon collagen fibril morphology,
abnormal thoracic cage shape,
abnormal trophoblast layer morphology,
decreased dendritic cell number,
decreased platelet alpha-granule number,
embryonic lethality during organogenesis, complete penetrance,
growth/size/body region phenotype,
increased macrophage cell number,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.