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XB-GENEPAGE-960476
chd1 chromodomain helicase DNA binding protein 1
Anatomical Phenotypes
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decreased width of the mouth (7 sources), abnormal craniofacial region morphology (6 sources), decreased size of the intercanthal region (6 sources), abnormal alimentary system morphology (3 sources), abnormal heart morphology (3 sources), abnormal tail morphology (3 sources), abnormal development of cranial neural crest (1 source), abnormal eye morphology (1 source), absent ethmoid bone (1 source), decreased size of the Meckel's cartilage (1 source), decreased size of the basihyal (1 source), decreased size of the ceratohyal (1 source), increased apoptosis in eye (1 source), increased apoptosis in head (1 source), increased apoptosis in tail (1 source) |
Expression Phenotypes
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Manual annotations: chd1 manipulated (5 sources), chd1 assayed (4 sources) |
Diseases
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orofacial cleft (10AP sources, 2 EP sources) |
Experiments (Reagents)
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Xla Wt + chd1 MO (4 sources), Xla Wt + chd1 MO (2 sources), Xla Wt + chd1 + animal cap explant (1 source), Xla Wt + chd1 + fermt2 MO + animal cap explant (1 source), Xla Wt + chd1 CRISPR (1 source), Xla Wt + chd1 MO (1 source), Xla Wt + chd1 MO (1 source), Xla Wt + chd1 MO + BMS453 (1 source), Xla Wt + chd1 MO + mouth transplant (1 source), Xla Wt + wnt3a + chd1 + animal cap explant (1 source) |
Monarch Ortholog Phenotypes
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Human (21 sources): Abnormal fingertip morphology, Allergy, Almond-shaped palpebral fissure, Autistic behavior, Broad eyebrow, Dermal translucency, Downslanted palpebral fissures, Failure to thrive, Frontal bossing, Generalized hypotonia, [+] |
Mouse (25 sources): abnormal craniofacial morphology, abnormal developmental patterning, abnormal embryo development, abnormal embryo size, abnormal maxilla morphology, abnormal mean corpuscular hemoglobin, abnormal mean corpuscular hemoglobin concentration, abnormal mesoderm development, abnormal red blood cell distribution width, abnormal rostral-caudal axis patterning, [+] |
View all ortholog results at Monarch |