| Monarch Ortholog Phenotypes
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Human (15 sources):
Delayed myelination,
Developmental regression,
Elevated circulating creatine kinase concentration,
Feeding difficulties,
Global developmental delay,
Growth delay,
Hyperreflexia,
Increased circulating lactate concentration,
Leukodystrophy,
Microcephaly,
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Mouse (20 sources):
abnormal egg cylinder morphology,
abnormal embryo size,
abnormal locomotor activation,
abnormal locomotor behavior,
abnormal pericardium morphology,
abnormal response to new environment,
absent head fold,
absent primitive node,
decreased embryo size,
decreased exploration in new environment,
decreased fasting circulating glucose level,
decreased locomotor activity,
decreased vertical activity,
embryonic growth arrest,
embryonic lethality prior to organogenesis,
embryonic lethality prior to tooth bud stage,
embryonic lethality, complete penetrance,
failure of primitive streak formation,
failure to gastrulate,
preweaning lethality, complete penetrance
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.