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XB-GENEPAGE-922515
trio trio Rho guanine nucleotide exchange factor
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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absent filopodium (2 sources), decreased cell migration in branchial crest (2 sources), decreased cell migration in cranial neural crest (2 sources), decreased cell migration in hyoid crest (2 sources), decreased cell migration in mandibular crest (2 sources), decreased size of the Meckel's cartilage (1 source), decreased size of the chondrocranium (1 source) |
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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Computed annotations: trio assayed (1 source) |
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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Xla Wt + trio MO (2 sources), Xla Wt + trio MO (1 source), Xla Wt + trio MO + neural crest explant (1 source), Xla Wt + trio MO + neural crest explant (1 source) |
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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Human (68 sources): 2-3 toe syndactyly, Abnormality of the dentition, Abnormality of the hand, Absent speech, Aggressive behavior, Amblyopia, Aplasia of the 1st metacarpal, Attention deficit hyperactivity disorder, Atypical behavior, Autistic behavior, [+] |
Mouse (24 sources): abnormal Bergmann glial cell morphology, abnormal cerebellar granule cell migration, abnormal cerebellar granule cell morphology, abnormal cerebellar granule layer morphology, abnormal cerebellum external granule cell layer morphology, abnormal cerebellum lobule morphology, abnormal dentate gyrus morphology, abnormal myogenesis, abnormal neuron differentiation, abnormal olfactory bulb mitral cell layer morphology, [+] |
View all ortholog results at Monarch |