Monarch Ortholog Phenotypes
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Human (47 sources):
Abnormal saccadic eye movements,
Abnormality of movement,
Abnormality of speech or vocalization,
Abnormality of the pulmonary artery,
Action tremor,
Agenesis of cerebellar vermis,
Aniridia,
Ataxia,
Broad-based gait,
Cerebellar atrophy,
Cerebellar hypoplasia,
Cerebellar vermis atrophy,
Cognitive impairment,
Delayed early-childhood social milestone development,
Delayed fine motor development,
Delayed gross motor development,
Delayed speech and language development,
Dysarthria,
Dysdiadochokinesis,
Dysmetria,
Dysmetric saccades,
Gait ataxia,
Gaze-evoked horizontal nystagmus,
Generalized hypotonia,
Global developmental delay,
Head tremor,
Hearing abnormality,
Hyperreflexia,
Hypoplasia of the iris,
Hypotonia,
Impaired smooth pursuit,
Intellectual disability,
Intention tremor,
Limb ataxia,
Mask-like facies,
Motor delay,
Nonprogressive cerebellar ataxia,
Nystagmus,
Oculomotor apraxia,
Postural tremor,
Scanning speech,
Slurred speech,
Tremor by anatomical site,
Truncal ataxia,
Upper limb postural tremor,
Visual fixation instability,
Visual impairment
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Mouse (29 sources):
abnormal CNS synaptic transmission,
abnormal Purkinje cell dendrite morphology,
abnormal Purkinje cell morphology,
abnormal embryo size,
abnormal excitatory postsynaptic currents,
abnormal excitatory postsynaptic potential,
abnormal forebrain development,
abnormal hindbrain development,
abnormal involuntary movement,
abnormal locomotor behavior,
abnormal locomotor coordination,
absent long term depression,
behavior/neurological phenotype,
decreased body size,
decreased brain size,
decreased circulating bilirubin level,
decreased insulin secretion,
impaired balance,
impaired righting response,
lethality at weaning, complete penetrance,
nervous system phenotype,
postnatal lethality, incomplete penetrance,
premature death,
prenatal lethality, incomplete penetrance,
preweaning lethality, complete penetrance,
preweaning lethality, incomplete penetrance,
small epididymis,
thin cerebellar molecular layer,
weakness
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View all ortholog results at Monarch
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