Monarch Ortholog Phenotypes
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Human (26 sources):
Anorexia,
Chronic oral candidiasis,
Decreased circulating IgG level,
Decreased circulating total IgA,
Decreased lymphocyte proliferation in response to mitogen,
Decreased proportion of CD3-positive T cells,
Diarrhea,
Eczematoid dermatitis,
Eosinophilia,
Erythroderma,
Failure to thrive secondary to recurrent infections,
Fever,
Hepatitis,
Hepatosplenomegaly,
Immunodeficiency,
Increased circulating antibody level,
Lymphopenia,
Otitis media,
Pneumonia,
Protracted diarrhea,
Recurrent abscess formation,
Recurrent candida infections,
Recurrent herpes,
Recurrent infections,
Recurrent pneumonia,
T lymphocytopenia
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Mouse (45 sources):
abnormal CD4-positive, alpha-beta T cell physiology,
abnormal CNS synaptic transmission,
abnormal NK T cell morphology,
abnormal T cell differentiation,
abnormal T cell proliferation,
abnormal T-helper 1 cell differentiation,
abnormal T-helper 1 cell morphology,
abnormal T-helper 1 physiology,
abnormal alpha-beta intraepithelial T cell morphology,
abnormal bone marrow cell physiology,
abnormal double-negative T cell morphology,
abnormal excitatory postsynaptic potential,
abnormal gamma-delta T cell differentiation,
abnormal intraepithelial T cell morphology,
abnormal lateral geniculate nucleus morphology,
abnormal long term depression,
abnormal regulatory T cell physiology,
abnormal single-positive T cell number,
abnormal superior colliculus morphology,
abnormal thymocyte activation,
absent gamma-delta intraepithelial T cell,
absent long term depression,
decreased CD4-positive, alpha beta T cell number,
decreased NK T cell number,
decreased T cell proliferation,
decreased double-positive T cell number,
decreased single-positive T cell number,
decreased splenocyte proliferation,
decreased thymocyte apoptosis,
decreased thymocyte number,
enhanced long term potentiation,
enlarged lateral ventricles,
enlarged lymph nodes,
enlarged thymus cortex,
immune system phenotype,
increased double-negative T cell number,
increased interferon-gamma secretion,
increased natural killer cell mediated cytotoxicity,
increased regulatory T cell number,
increased susceptibility to experimental autoimmune encephalomyelitis,
no abnormal phenotype detected,
postnatal lethality, complete penetrance,
reduced long term depression,
small thymus,
small thymus medulla
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View all ortholog results at Monarch
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