| Monarch Ortholog Phenotypes
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Human (7 sources):
Autoimmunity,
Decreased proportion of CD4-positive helper T cells,
Diarrhea,
Failure to thrive,
Immunodeficiency,
Panniculitis,
Recurrent respiratory infections
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Mouse (33 sources):
abnormal CD4-positive T cell differentiation,
abnormal CD4-positive, alpha beta T cell morphology,
abnormal CD8-positive, alpha beta T cell morphology,
abnormal CD8-positive, alpha-beta T cell differentiation,
abnormal T cell differentiation,
abnormal T cell subpopulation ratio,
abnormal alpha-beta intraepithelial T cell morphology,
abnormal double-negative T cell morphology,
abnormal intraepithelial T cell morphology,
abnormal intraepithelial T cell number,
abnormal regulatory T cell physiology,
abnormal single-positive T cell number,
abnormal thymocyte activation,
abnormal thymus morphology,
decreased CD4-positive, alpha beta T cell number,
decreased IgG1 level,
decreased T cell proliferation,
decreased cytotoxic T cell cytolysis,
decreased double-positive T cell number,
decreased gamma-delta T cell number,
decreased gamma-delta intraepithelial T cell number,
decreased regulatory T cell number,
decreased single-positive T cell number,
decreased thymocyte number,
enlarged lymph nodes,
increased IgG2a level,
increased IgG3 level,
increased T cell derived lymphoma incidence,
increased activated T cell number,
increased regulatory T cell number,
increased single-positive T cell number,
premature death,
thymus atrophy
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.