Ankle flexion contracture, Aplasia/Hypoplasia of the corpus callosum, Areflexia, Ataxia, Babinski sign, Bulbar signs, Cerebral cortical atrophy, Cognitive impairment, Decreased muscle mass, Decreased number of peripheral myelinated nerve fibers, Degeneration of the lateral corticospinal tracts, Distal amyotrophy, Distal muscle weakness, Distal peripheral sensory neuropathy, Distal sensory impairment, Dysarthria, Dysphagia, EMG abnormality, Fasciculations, Foot dorsiflexor weakness, Gait disturbance, Gaze-evoked nystagmus, Hyperreflexia, Hypoplasia of the corpus callosum, Impaired vibration sensation in the lower limbs, Intellectual disability, Knee clonus, Kyphoscoliosis, Lower limb muscle weakness, Lower limb spasticity, Macular degeneration, Mental deterioration, Motor polyneuropathy, Nystagmus, Obesity, Peripheral axonal neuropathy, Peripheral neuropathy, Pes cavus, Pseudobulbar affect, Reduced tendon reflexes, Respiratory insufficiency due to muscle weakness, Retinal degeneration, Saccadic smooth pursuit, Seizure, Sensory neuropathy, Skeletal muscle atrophy, Spastic gait, Spastic paraplegia, Spasticity, Specific learning disability, Thenar muscle atrophy, Tip-toe gait, Tremor, Urinary bladder sphincter dysfunction, Urinary incontinence, Urinary urgency, Ventriculomegaly, Visual impairment