| Monarch Ortholog Phenotypes
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Human (8 sources):
Diarrhea,
Failure to thrive,
Hypercholesterolemia,
Hyperlipidemia,
Hypoalbuminemia,
Protein-losing enteropathy,
Villous atrophy,
Vomiting
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Mouse (27 sources):
abnormal branching of the mammary ductal tree,
abnormal digestion,
abnormal hair cycle,
abnormal hair cycle anagen phase,
abnormal hair shedding,
abnormal mammary gland alveolus morphology,
abnormal mammary gland development,
abnormal mammary gland epithelium morphology,
abnormal mammary gland growth during lactation,
abnormal milk composition,
abnormal skin condition,
abnormal vitamin A level,
decreased circulating glucose level,
decreased liver cholesterol level,
decreased liver triglyceride level,
decreased mammary fat pad weight,
decreased mammary gland epithelial cell proliferation,
decreased percent body fat/body weight,
decreased susceptibility to diet-induced obesity,
decreased susceptibility to hepatic steatosis,
epidermal hyperplasia,
impaired mammary gland growth during pregnancy,
improved glucose tolerance,
increased insulin sensitivity,
increased oxygen consumption,
lactation failure,
skin lesions
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.