Monarch Ortholog Phenotypes
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Human (27 sources):
Abnormal respiratory system physiology,
Agitation,
Amyotrophic lateral sclerosis,
Anxiety,
Degeneration of anterior horn cells,
Depression,
Dysarthria,
Dysphagia,
Dyspnea,
Emotional lability,
Fasciculations,
Fatigable weakness of bulbar muscles,
Fatigable weakness of respiratory muscles,
Fatigable weakness of swallowing muscles,
Fatigue,
Generalized muscle weakness,
Laryngospasm,
Muscle spasm,
Muscle weakness,
Nausea and vomiting,
Neurodegeneration,
Pain,
Paralysis,
Respiratory insufficiency,
Skeletal muscle atrophy,
Spasticity,
Xerostomia
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Mouse (27 sources):
abnormal chondrocyte differentiation,
abnormal chondrocyte physiology,
abnormal circulating magnesium level,
abnormal long bone epiphyseal plate proliferative zone,
abnormal long bone hypertrophic chondrocyte zone,
abnormal skeleton development,
abnormal vascular endothelial cell migration,
abnormal vascular wound healing,
decreased angiogenesis,
decreased body length,
decreased body size,
decreased bone mineral content,
decreased circulating fructosamine level,
decreased survivor rate,
delayed wound healing,
embryonic lethality before implantation, complete penetrance,
fused cornea and lens,
improved glucose tolerance,
increased circulating amylase level,
increased width of hypertrophic chondrocyte zone,
lethality, complete penetrance,
no abnormal phenotype detected,
perinatal lethality, incomplete penetrance,
postnatal lethality, incomplete penetrance,
prenatal lethality, incomplete penetrance,
preweaning lethality, complete penetrance,
weakness
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View all ortholog results at Monarch
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