Monarch Ortholog Phenotypes
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Mouse (44 sources):
abnormal Purkinje cell dendrite morphology,
abnormal Purkinje cell differentiation,
abnormal adipose tissue amount,
abnormal bile salt homeostasis,
abnormal bone mineralization,
abnormal cardiac muscle contractility,
abnormal cardiac output,
abnormal cerebellar granule cell morphology,
abnormal cerebellar molecular layer,
abnormal cerebellum development,
abnormal cerebellum external granule cell layer morphology,
abnormal circadian temperature homeostasis,
abnormal eye anterior chamber depth,
abnormal eye posterior chamber depth,
abnormal heart left ventricle size,
abnormal skeletal muscle fiber type ratio,
advanced circadian behavior phase,
decreased cardiac muscle contractility,
decreased cardiac output,
decreased cardiac stroke volume,
decreased circulating alkaline phosphatase level,
decreased heart left ventricle size,
decreased litter size,
decreased liver cholesterol level,
decreased liver triglyceride level,
decreased locomotor activity,
decreased sensitivity to induced morbidity/mortality,
decreased susceptibility to induced hypothermia,
decreased thigmotaxis,
decreased total retina thickness,
decreased vertical activity,
increased adipocyte glucose uptake,
increased body temperature,
increased bone mineral content,
increased core body temperature,
increased lean body mass,
increased oxygen consumption,
increased skeletal muscle fiber size,
postnatal lethality, incomplete penetrance,
preweaning lethality, incomplete penetrance,
reduced female fertility,
reduced male fertility,
shortened circadian behavior period,
thin ventricular wall
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