Monarch Ortholog Phenotypes
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Mouse (32 sources):
abnormal circulating cholesterol level,
abnormal eye electrophysiology,
abnormal hepatocyte morphology,
abnormal locomotor behavior,
abnormal proximal convoluted tubule morphology,
abnormal renal tubule epithelial cell primary cilium morphology,
abnormal retina outer nuclear layer morphology,
abnormal seminiferous tubule morphology,
cellular phenotype,
crystalluria,
decreased eosinophil cell number,
degranulated pancreatic beta cells,
dilated proximal convoluted tubule,
dilated renal tubules,
increased body size,
increased fasting circulating glucose level,
increased food intake,
increased kidney apoptosis,
increased kidney cell proliferation,
increased kidney weight,
increased liver weight,
increased or absent threshold for auditory brainstem response,
increased susceptibility to weight gain,
increased total body fat amount,
increased white adipose tissue amount,
macrovesicular hepatic steatosis,
microvesicular hepatic steatosis,
pancreatic islet hyperplasia,
retina outer nuclear layer degeneration,
retina photoreceptor degeneration,
retina pigment epithelium atrophy,
seminiferous tubule degeneration
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