nox4 Phenotypes

Phenotypes

XB-GENEPAGE-1012417

Gene Symbol: nox4 Gene Name: NADPH oxidase 4

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: nox4 assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (36 sources): abnormal blood-brain barrier function, abnormal circulating calcium level, abnormal circulating total protein level, abnormal mitochondrial physiology, abnormal redox activity, abnormal response/metabolism to endogenous compounds, abnormal ventricle myocardium morphology, cardiac fibrosis, cardiac hypertrophy, cardiac interstitial fibrosis, cardiovascular system phenotype, decreased apoptosis, decreased cardiac muscle contractility, decreased cardiomyocyte apoptosis, decreased cerebral infarct size, decreased interleukin-1 beta secretion, decreased kidney apoptosis, decreased neuron apoptosis, decreased physiological sensitivity to xenobiotic, decreased renal tubule apoptosis, decreased response of heart to induced stress, decreased sensitivity to induced morbidity/mortality, decreased susceptibility to endotoxin shock, decreased susceptibility to ischemic brain injury, decreased susceptibility to weight loss, decreased tumor necrosis factor secretion, decreased ventricle muscle contractility, dilated heart, enlarged lymph nodes, increased cardiomyocyte apoptosis, increased heart weight, increased left ventricle weight, increased response of heart to induced stress, oxidative stress, shortened RR interval, thick interventricular septum [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (36 sources): abnormal blood-brain barrier function, abnormal circulating calcium level, abnormal circulating total protein level, abnormal mitochondrial physiology, abnormal redox activity, abnormal response/metabolism to endogenous compounds, abnormal ventricle myocardium morphology, cardiac fibrosis, cardiac hypertrophy, cardiac interstitial fibrosis, [+]