sox2 Expression

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Summary

Expression

Phenotypes

Gene Literature (545)

XB-GENEPAGE-484552

Gene Symbol: sox2

Gene Name: SRY-box 2

Anatomy terms

Keller explant Rohon-Beard neuron alimentary system animal cap animal hemisphere animal pole anterior anterior neural fold anterior neural ridge anterior neural tube anterior placodal area blastopore lip brain ... [+]

RNA-Seq and EST Transcriptome profiles	???displayGene.tropicalis???	???displayGene.laevis???.L	???displayGene.laevis???.S
RNA-Seq stage profile	Data from Owens et al. 2016	Data from Session et al. 2016	Data from Session et al. 2016
???displayGene.geoData???		sox2.L	sox2.S
Microarray Data	Data from Yanai et al. 2011	Data from Yanai et al. 2011	Data from Yanai et al. 2011

Stage and Tissue Profiles

Source: Owens et al. 2016 (tropicalis)

Source: Session et al. 2016 (laevis)

Experimental Regulation (via RNA-seq)

Source: Ding et al. 2017 (laevis)

Summary Images

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NF stage 13	NF stage 16	NF stage 18	NF stage 25	NF stage 25	3 more [+]

Community Submitted Images

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NF stage 10	NF stage 10	NF stage 10	NF stage 10	NF stage 10	32 more [+]

Literature Images

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NF stage 9 Sempou, et al. 2022	NF stage 10 Fletcher, et al. 2008	NF stage 10 Sasai, et al. 2008	NF stage 10 Gao, et al. 2015	NF stage 10 Gao, et al. 2015	431 more [+]

NF stage 10.25 de Almeida, et al. 2008	NF stage 10.5 Delaune, et al. 2005	NF stage 10.5 Galli, et al. 2003	NF stage 9 to NF stage 10.5 Sudou, et al. 2012	NF stage 10.5 Cao, et al. 2012
NF stage 10.5 Cao, et al. 2012	NF stage 10.5 Gawantka, et al. 1998	NF stage 10.5 Julier, et al. 2012	NF stage 10.5 Zheng, et al. 2015	NF stage 10.5 Scerbo, et al. 2017
NF stage 10.5 Scerbo, et al. 2017	NF stage 11 van Grunsven, et al. 2007	NF stage 11 Yan, et al. 2009	NF stage 11 Siegel, et al. 2009	NF stage 11 Schuff, et al. 2010
NF stage 11 Revinski, et al. 2010	NF stage 11 Revinski, et al. 2010	NF stage 11 Wills, et al. 2006	NF stage 11 Cao, et al. 2012	NF stage 11 Cao, et al. 2012
NF stage 11 Wills, et al. 2006	NF stage 11 Moody, et al. 2013	NF stage 11 Marchak, et al. 2017	NF stage 11 Marchak, et al. 2017	NF stage 11.5 Sasai, et al. 2008
NF stage 10.5 to NF stage 11.5 Hufton, et al. 2006	NF stage 12 Galli, et al. 2003	NF stage 12 Rogers, et al. 2009	NF stage 12 Neuner, et al. 2009	NF stage 12 Li, et al. 2009
NF stage 12 Oelgeschläger, et al. 2003	NF stage 12 Kuriyama, et al. 2001	NF stage 12 Steventon, et al. 2012	NF stage 12 Agüero, et al. 2012	NF stage 12 Alkobtawi, et al. 2021
NF stage 10 to NF stage 12.5 Fetka, et al. 2000	NF stage 12.5 Yoder, et al. 2011	NF stage 12.5 Zheng, et al. 2015	NF stage 13 Woda, et al. 2003	NF stage 10.5 to NF stage 13 Hikasa, et al. 2004
NF stage 13 Delaune, et al. 2005	NF stage 10.5 to NF stage 13 Delaune, et al. 2005	NF stage 13 Andreazzoli, et al. 2003	NF stage 13 Bardine, et al. 2009	NF stage 13 Kim, et al. 2005
NF stage 13 Morrison, et al. 2006	NF stage 13 Tríbulo, et al. 2012	NF stage 13 Lim, et al. 2011	NF stage 13 Cousin, et al. 2004	NF stage 13 Murgan, et al. 2014
NF stage 13 Murgan, et al. 2014	NF stage 13 Yamamoto, et al. 2005	NF stage 13 Scerbo, et al. 2017	NF stage 14 Luo, et al. 2007	NF stage 13 to NF stage 14 Schlosser, et al. 2004
NF stage 13 to NF stage 14 Schlosser, et al. 2004	NF stage 14 Takebayashi-Suzuki, et al. 2007	NF stage 14 Khokha, et al. 2005	NF stage 14 Delaune, et al. 2005	NF stage 14 Dichmann, et al. 2008
NF stage 14 van Grunsven, et al. 2007	NF stage 13 to NF stage 14 Mamada, et al. 2009	NF stage 13 to NF stage 14 Mamada, et al. 2009	NF stage 11 to NF stage 14 Kuriyama, et al. 2009	NF stage 14 Olivares, et al. 2009
NF stage 10.5 to NF stage 14 Yan, et al. 2009	NF stage 11 to NF stage 14 Yan, et al. 2009	NF stage 14 Khadka, et al. 2009	NF stage 13 to NF stage 14 Revinski, et al. 2010	NF stage 14 Revinski, et al. 2010
NF stage 14 Habas, et al. 2001	NF stage 14 Sato, et al. 2006	NF stage 14 Wallingford, et al. 2002	NF stage 14 Shibata, et al. 2005	NF stage 14 Min, et al. 2011
NF stage 14 Min, et al. 2011	NF stage 14 Min, et al. 2011	NF stage 14 Agüero, et al. 2012	NF stage 14 Agüero, et al. 2012	NF stage 14 Agüero, et al. 2012
NF stage 13 to NF stage 14 Wei, et al. 2012	NF stage 14 Xu, et al. 2012	NF stage 14 Kuriyama, et al. 2009	NF stage 14 Kuriyama, et al. 2009	NF stage 14 Kuriyama, et al. 2009
NF stage 14 Nishimoto, et al. 2007	NF stage 14 Kurata, et al. 2003	NF stage 14 Fernández, et al. 2014	NF stage 14 Khadka, et al. 2006	NF stage 14 Nitta, et al. 2007
NF stage 14 Janesick, et al. 2013	NF stage 14 Moody, et al. 2013	NF stage 14 Liu, et al. 2008	NF stage 14 Piccolo, et al. 1997	NF stage 14 Young, et al. 2017
NF stage 12.5 to NF stage 14 Plouhinec, et al. 2017	NF stage 12.5 to NF stage 14 Plouhinec, et al. 2017	NF stage 14 Manojlovic, et al. 2017	NF stage 14 Borday, et al. 2018	NF stage 14 Bae, et al. 2018
NF stage 14 Borday, et al. 2018	NF stage 14 Devotta, et al. 2018	NF stage 14 Harata, et al. 2019	NF stage 14 Naef, et al. 2018	NF stage 14 Kulkarni, et al. 2018
NF stage 14 Moore, et al. 2018	NF stage 14 Néant, et al. 2015	NF stage 14 Pla, et al. 2018	NF stage 14 to NF stage 15 Huang, et al. 2007	NF stage 14 to NF stage 15 Khokha, et al. 2005
NF stage 14 to NF stage 15 Khokha, et al. 2005	NF stage 15 Blitz, et al. 2003	NF stage 15 Kuriyama, et al. 2006	NF stage 15 Wu, et al. 2001	NF stage 15 Bonano, et al. 2008
NF stage 15 Hong, et al. 2008	NF stage 15 Hou, et al. 2007	NF stage 12 to NF stage 15 Matsuo-Takasaki, et al. 2005	NF stage 14 to NF stage 15 Matsuo-Takasaki, et al. 2005	NF stage 14 to NF stage 15 Matsuo-Takasaki, et al. 2005
NF stage 15 Matsuo-Takasaki, et al. 2005	NF stage 15 Reversade, et al. 2005	NF stage 6 (32-cell) to NF stage 15 Klymkowsky, et al. 2010	NF stage 15 Heeg-Truesdell, et al. 2006	NF stage 14 to NF stage 15 Ossipova, et al. 2011
NF stage 14 to NF stage 15 Ossipova, et al. 2011	NF stage 15 Thomas, et al. 2009	NF stage 11 to NF stage 15 Sudou, et al. 2012	NF stage 15 Tanibe, et al. 2012	NF stage 15 Suzuki, et al. 2010
NF stage 15 Steventon, et al. 2012	NF stage 12 to NF stage 15 Bonacci, et al. 2012	NF stage 15 LeSueur, et al. 2002	NF stage 15 Green, et al. 2011	NF stage 15 Wang, et al. 2013
NF stage 15 Fernández, et al. 2014	NF stage 15 Matsukawa, et al. 2015	NF stage 15 Matsukawa, et al. 2015	NF stage 15 Matsukawa, et al. 2015	NF stage 15 Dichmann, et al. 2015
NF stage 15 Vitorino, et al. 2015	NF stage 15 Kurauchi, et al. 2010	NF stage 15 Devotta, et al. 2016	NF stage 12 to NF stage 15 Iimura, et al. 2016	NF stage 15 Hatch, et al. 2016
NF stage 15 Hatch, et al. 2016	NF stage 15 Vega-López, et al. 2015	NF stage 15 Chang, et al. 2006	NF stage 15 Yokota, et al. 2017	NF stage 14 to NF stage 15 Hong, et al. 2017
NF stage 15 Vacca, et al. 2018	NF stage 15 Bradley, et al. 2018	NF stage 15 Vacca, et al. 2018	NF stage 15 Cerrizuela, et al. 2018	NF stage 15 Moore, et al. 2018
NF stage 15 Hatch, et al. 2016	NF stage 15 Rao, et al. 2018	NF stage 15 Devotta, et al. 2023	NF stage 16 Langer, et al. 2008	NF stage 16 Van Campenhout, et al. 2006
NF stage 16 Ueno, et al. 2008	NF stage 16 Sasai, et al. 2001	NF stage 16 Sasai, et al. 2001	NF stage 14 to NF stage 16 Kuriyama, et al. 2009	NF stage 14 to NF stage 16 Ossipova, et al. 2011
NF stage 14 to NF stage 16 Ossipova, et al. 2011	NF stage 14 to NF stage 16 Ossipova, et al. 2011	NF stage 14 to NF stage 16 Ossipova, et al. 2011	NF stage 16 van Venrooy, et al. 2008	NF stage 16 Tríbulo, et al. 2012
NF stage 16 Tríbulo, et al. 2012	NF stage 16 Tríbulo, et al. 2012	NF stage 15 to NF stage 16 Suzuki, et al. 2010	NF stage 15 to NF stage 16 Nicetto, et al. 2013	NF stage 16 Kurata, et al. 2003
NF stage 16 Kurata, et al. 2003	NF stage 16 Fernández, et al. 2014	NF stage 16 Hulstrand, et al. 2013	NF stage 16 Hulstrand, et al. 2013	NF stage 16 Hong, et al. 2014
NF stage 16 Barrionuevo, et al. 2014	NF stage 16 Olguín, et al. 2006	NF stage 16 Zhang, et al. 2014	NF stage 15 to NF stage 16 Vega-López, et al. 2015	NF stage 15 to NF stage 16 Vega-López, et al. 2015
NF stage 15 to NF stage 16 Vega-López, et al. 2015	NF stage 16 Chang, et al. 2006	NF stage 16 Exner, et al. 2017	NF stage 16 Exner, et al. 2017	NF stage 16 Suzuki, et al. 2017
NF stage 16 Belgacem, et al. 2015	NF stage 16 Belgacem, et al. 2015	NF stage 16 Leal, et al. 2018	NF stage 15 to NF stage 16 Cerrizuela, et al. 2018	NF stage 15 to NF stage 16 Cerrizuela, et al. 2018
NF stage 15 to NF stage 16 Cerrizuela, et al. 2018	NF stage 16 Gouignard, et al. 2023	NF stage 17 O'Donnell, et al. 2006	NF stage 17 Chang, et al. 2007	NF stage 17 Andreazzoli, et al. 2003
NF stage 17 Schlosser, et al. 2008	NF stage 17 Schlosser, et al. 2008	NF stage 17 Kuriyama, et al. 2006	NF stage 17 Rogers, et al. 2009	NF stage 16 to NF stage 17 Hwang, et al. 2009
NF stage 17 Siegel, et al. 2009	NF stage 12 to NF stage 17 Wills, et al. 2010	NF stage 14 to NF stage 17 Dichmann, et al. 2011	NF stage 10.5 to NF stage 17 Rogers, et al. 2008	NF stage 16 to NF stage 17 Shibata, et al. 2005
NF stage 14 to NF stage 17 Neant, et al. 2011	NF stage 17 LaBonne, et al. 1998	NF stage 17 Lee, et al. 2004	NF stage 14 to NF stage 17 Alexandrova, et al. 2006	NF stage 15 to NF stage 17 Geach, et al. 2014
NF stage 17 Ma, et al. 2017	NF stage 16 to NF stage 17 Li, et al. 2017	NF stage 16 to NF stage 17 Li, et al. 2017	NF stage 17 Lee, et al. 2018	NF stage 18 Chang, et al. 2007
NF stage 15 to NF stage 18 Chang, et al. 2007	NF stage 18 Chang, et al. 2007	NF stage 18 Chang, et al. 2007	NF stage 17 to NF stage 18 Takebayashi-Suzuki, et al. 2007	NF stage 18 Abu-Elmagd, et al. 2006
NF stage 10.5 to NF stage 18 Rogers, et al. 2008	NF stage 12 to NF stage 18 Glavic, et al. 2004	NF stage 18 Dichmann, et al. 2008	NF stage 18 Bonano, et al. 2008	NF stage 18 Linker, et al. 2009
NF stage 18 Rodríguez-Seguel, et al. 2009	NF stage 18 Olivares, et al. 2009	NF stage 18 Ossipova, et al. 2009	NF stage 18 Garcia-Morales, et al. 2009	NF stage 18 Garcia-Morales, et al. 2009
NF stage 18 Garcia-Morales, et al. 2009	NF stage 14 to NF stage 18 Wills, et al. 2010	NF stage 17 to NF stage 18 Brugmann, et al. 2004	NF stage 18 Schneider, et al. 2010	NF stage 18 Seo, et al. 2005
NF stage 18 Takebayashi-Suzuki, et al. 2011	NF stage 18 Takebayashi-Suzuki, et al. 2011	NF stage 18 Gee, et al. 2011	NF stage 18 Logan, et al. 2005	NF stage 17 to NF stage 18 LaBonne, et al. 2000
NF stage 18 LaBonne, et al. 1998	NF stage 18 LaBonne, et al. 1998	NF stage 18 Das, et al. 2012	NF stage 18 Das, et al. 2012	NF stage 18 Wessely, et al. 2005
NF stage 18 Ioannou, et al. 2013	NF stage 18 Roche, et al. 2009	NF stage 16 to NF stage 18 Roche, et al. 2009	NF stage 18 Roche, et al. 2009	NF stage 18 Kurata, et al. 2003
NF stage 18 Kim, et al. 2011	NF stage 18 Zhang, et al. 2014	NF stage 18 Cavodeassi, et al. 2001	NF stage 18 Nakajima, et al. 2009	NF stage 18 Young, et al. 2014
NF stage 18 Young, et al. 2014	NF stage 18 Young, et al. 2014	NF stage 18 Young, et al. 2014	NF stage 14 to NF stage 18 Olguín, et al. 2006	NF stage 18 Olguín, et al. 2006
NF stage 18 Mayor, et al. 1997	NF stage 18 Deichmann, et al. 2015	NF stage 18 Schille, et al. 2016	NF stage 18 Schille, et al. 2016	NF stage 18 Schille, et al. 2016
NF stage 14 to NF stage 18 Piccolo, et al. 1997	NF stage 18 Riddiford, et al. 2016	NF stage 18 Riddiford, et al. 2016	NF stage 18 Riddiford, et al. 2016	NF stage 18 Neilson, et al. 2017
NF stage 18 Neilson, et al. 2017	NF stage 18 Marchak, et al. 2017	NF stage 18 Puvirajesinghe, et al. 2016	NF stage 14 to NF stage 18 Balashova, et al. 2017	NF stage 15 to NF stage 18 Balashova, et al. 2017
NF stage 14 to NF stage 18 Figueiredo, et al. 2017	NF stage 18 Figueiredo, et al. 2017	NF stage 18 Xia, et al. 2012	NF stage 18 Olguín, et al. 2006	NF stage 18 Hardwick, et al. 2019
NF stage 13 to NF stage 18 Neilson, et al. 2020	NF stage 16 to NF stage 18 Tavares, et al. 2021	NF stage 18 Pandey, et al. 2023	NF stage 19 Zhao, et al. 2008	NF stage 18 to NF stage 19 Tribulo, et al. 2003
NF stage 19 Aybar, et al. 2003	NF stage 19 van Grunsven, et al. 2007	NF stage 14 to NF stage 19 Wills, et al. 2010	NF stage 19 Gutkovich, et al. 2010	NF stage 15 to NF stage 19 Maldonado-Agurto, et al. 2011
NF stage 19 Kuriyama, et al. 2009	NF stage 19 Kim, et al. 2011	NF stage 19 Iwasaki, et al. 2014	NF stage 19 De Marco, et al. 2011	NF stage 19 Schwenty-Lara, et al. 2020
NF stage 20 Borchers, et al. 2006	NF stage 20 Bonano, et al. 2008	NF stage 20 Yan, et al. 2009	NF stage 20 Gutkovich, et al. 2010	NF stage 20 Zaghloul, et al. 2007
NF stage 20 Zaghloul, et al. 2007	NF stage 20 Zaghloul, et al. 2007	NF stage 20 Zaghloul, et al. 2007	NF stage 18 to NF stage 20 Reversade, et al. 2005	NF stage 20 Reversade, et al. 2005
NF stage 20 Fletcher, et al. 2006	NF stage 20 Fletcher, et al. 2006	NF stage 20 Fletcher, et al. 2006	NF stage 15 to NF stage 20 Kuriyama, et al. 2001	NF stage 15 to NF stage 20 Kuriyama, et al. 2001
NF stage 20 Kuriyama, et al. 2009	NF stage 20 Pfister, et al. 2012	NF stage 20 de Almeida, et al. 2008	NF stage 19 to NF stage 20 de Almeida, et al. 2008	NF stage 20 de Almeida, et al. 2008
NF stage 20 de Almeida, et al. 2008	NF stage 20 Almeida, et al. 2010	NF stage 20 Armisén, et al. 2002	NF stage 20 Popov, et al. 2017	NF stage 19 to NF stage 20 Rabadán, et al. 2016
NF stage 20 Takebayashi-Suzuki, et al. 2018	NF stage 20 Takebayashi-Suzuki, et al. 2018	NF stage 15 to NF stage 20 Katada, et al. 2019	NF stage 21 Liu, et al. 2005	NF stage 19 to NF stage 21 Borchers, et al. 2006
NF stage 13 to NF stage 21 Wills, et al. 2010	NF stage 13 to NF stage 21 Guémar, et al. 2007	NF stage 13 to NF stage 21 Wallingford, et al. 2002	NF stage 13 to NF stage 21 Luo, et al. 2003	NF stage 13 to NF stage 21 Whittington, et al. 2015
NF stage 21 Olguín, et al. 2006	NF stage 7 to NF stage 21 Buitrago-Delgado, et al. 2018	NF stage 21 to NF stage 22 Schlosser, et al. 2004	NF stage 22 Lee, et al. 2006	NF stage 22 Wills, et al. 2010
NF stage 22 Takebayashi-Suzuki, et al. 2011	NF stage 22 Eivers, et al. 2009	NF stage 14 to NF stage 22 Vignali, et al. 2000	NF stage 10 to NF stage 22 Szenker, et al. 2012	NF stage 23 Sasai, et al. 2001
NF stage 17 to NF stage 23 Spokony, et al. 2002	NF stage 23 Agathocleous, et al. 2009	NF stage 24 Rossi, et al. 2008	NF stage 24 Neuner, et al. 2009	NF stage 24 Wills, et al. 2010
NF stage 24 Malartre, et al. 2006	NF stage 24 Chang, et al. 2006	NF stage 24 to NF stage 25 Rossi, et al. 2008	NF stage 25 Gómez-Skarmeta, et al. 1999	NF stage 25 Scerbo, et al. 2017
NF stage 13 to NF stage 25 Le Petillon, et al. 2017	NF stage 25 Le Petillon, et al. 2017	NF stage 25 Le Petillon, et al. 2017	NF stage 26 Schlosser, et al. 2008	NF stage 18 to NF stage 26 Puvirajesinghe, et al. 2016
NF stage 24 to NF stage 27 Schlosser, et al. 2004	NF stage 28 Chang, et al. 2007	NF stage 28 Willardsen, et al. 2009	NF stage 19 to NF stage 28 Nichane, et al. 2008	NF stage 28 Gómez-Skarmeta, et al. 1999
NF stage 11 to NF stage 28 Voigt, et al. 2005	NF stage 28 Parlier, et al. 2013	NF stage 28 Willardsen, et al. 2014	NF stage 27 to NF stage 28 Belotti, et al. 2013	NF stage 28 Riddiford, et al. 2016
NF stage 28 Riddiford, et al. 2016	NF stage 24 to NF stage 28 Sullivan, et al. 2019	NF stage 29 and 30 Lupo, et al. 2002	NF stage 29 and 30 Day, et al. 2011	NF stage 29 and 30 Christine, et al. 2008
NF stage 10.5 to NF stage 29 and 30 Gawantka, et al. 1998	NF stage 10.5 to NF stage 29 and 30 Gawantka, et al. 1998	NF stage 28 to NF stage 32 Barnett, et al. 2012	NF stage 15 to NF stage 32 Zhang, et al. 2017	NF stage 32 to NF stage 33 and 34 Schlosser, et al. 2004
NF stage 29 and 30 to NF stage 33 and 34 David, et al. 2001	NF stage 32 to NF stage 33 and 34 Rankin, et al. 2012	NF stage 33 and 34 Chung, et al. 2014	NF stage 33 and 34 Rankin, et al. 2016	NF stage 33 and 34 Nakayama, et al. 2017
NF stage 35 and 36 Park, et al. 2010	NF stage 35 and 36 Elkins, et al. 2006	NF stage 33 and 34 to NF stage 35 and 36 Rankin, et al. 2012	NF stage 33 and 34 to NF stage 35 and 36 Rankin, et al. 2012	NF stage 35 and 36 Rankin, et al. 2012
NF stage 14 to NF stage 35 and 36 Senturker, et al. 2012	NF stage 17 to NF stage 35 and 36 Moreno, et al. 2005	NF stage 35 and 36 Pfirrmann, et al. 2015	NF stage 33 and 34 to NF stage 35 and 36 Rankin, et al. 2012	NF stage 35 and 36 Rankin, et al. 2016
NF stage 35 and 36 Stevens, et al. 2017	NF stage 22 to NF stage 37 and 38 Zaghloul, et al. 2007	NF stage 37 and 38 Langdon, et al. 2007	NF stage 37 and 38 Moreno, et al. 2017	NF stage 37 and 38 Rankin, et al. 2018
NF stage 33 and 34 to NF stage 37 and 38 Rankin, et al. 2018	NF stage 39 Agathocleous, et al. 2009	NF stage 40 Damianitsch, et al. 2009	NF stage 40 Damianitsch, et al. 2009	NF stage 41 Kelly, et al. 2007
NF stage 41 Chalmers, et al. 2000	NF stage 41 Love, et al. 2014	NF stage 12 to NF stage 42 Oelgeschläger, et al. 2003	NF stage 40 to NF stage 42 Pandur, et al. 2000	NF stage 33 and 34 to NF stage 42 Rankin, et al. 2012
NF stage 42 Rankin, et al. 2012	NF stage 32 to NF stage 42 Rankin, et al. 2015	NF stage 37 and 38 to NF stage 42 Moreno, et al. 2017	NF stage 35 and 36 to NF stage 42 Nasr, et al. 2019	NF stage 1 to NF stage 44 De Robertis, et al. 2009
NF stage 13 to NF stage 44 Scerbo, et al. 2017	NF stage 44 Nasr, et al. 2019	NF stage 42 to NF stage 45 Park, et al. 2007	NF stage 45 Love, et al. 2014	NF stage 41 to NF stage 46 Pilcher, et al. 2002
NF stage 42 to NF stage 46 Tereshina, et al. 2011	NF stage 46 to NF stage 47 Chalmers, et al. 2000	NF stage 47 Martinez-De Luna, et al. 2011	NF stage 48 McKeown, et al. 2019	NF stage 50 Méndez-Olivos, et al. 2017
NF stage 46 to NF stage 54 Moreno, et al. 2017	NF stage 32 to NF stage 59 Rankin, et al. 2015	NF stage 45 to NF stage 66 Gaete, et al. 2012	NF stage 54 to NF stage 66 Tapia, et al. 2017	NF stage 50 to NF stage 66 Tapia, et al. 2017
NF stage 66 Méndez-Olivos, et al. 2017