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Summary Expression Phenotypes Gene Literature (117) GO Terms (4) Nucleotides (52) Proteins (37) Interactants (118) Wiki

Papers associated with kcna2

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Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine., Manville RW, Abbott GW., J Pharmacol Exp Ther. June 1, 2020; 373 (3): 391-401.

Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels., Bu W, Liang Q, Zhi L, Maciunas L, Loll PJ, Eckenhoff RG, Covarrubias M., Mol Neurobiol. February 1, 2018; 55 (2): 1692-1702.

Clinical spectrum and genotype-phenotype associations of KCNA2-related encephalopathies., Masnada S, Hedrich UBS, Gardella E, Schubert J, Kaiwar C, Klee EW, Lanpher BC, Gavrilova RH, Synofzik M, Bast T, Gorman K, King MD, Allen NM, Conroy J, Ben Zeev B, Tzadok M, Korff C, Dubois F, Ramsey K, Narayanan V, Serratosa JM, Giraldez BG, Helbig I, Marsh E, O'Brien M, Bergqvist CA, Binelli A, Porter B, Zaeyen E, Horovitz DD, Wolff M, Marjanovic D, Caglayan HS, Arslan M, Pena SDJ, Sisodiya SM, Balestrini S, Syrbe S, Veggiotti P, Lemke JR, Møller RS, Lerche H, Rubboli G., Brain. September 1, 2017; 140 (9): 2337-2354.

C-Terminal residues in small potassium channel blockers OdK1 and OSK3 from scorpion venom fine-tune the selectivity., Kuzmenkov AI, Peigneur S, Chugunov AO, Tabakmakher VM, Efremov RG, Tytgat J, Grishin EV, Vassilevski AA., Biochim Biophys Acta Proteins Proteom. May 1, 2017; 1865 (5): 465-472.

Dominant KCNA2 mutation causes episodic ataxia and pharmacoresponsive epilepsy., Corbett MA, Bellows ST, Li M, Carroll R, Micallef S, Carvill GL, Myers CT, Howell KB, Maljevic S, Lerche H, Gazina EV, Mefford HC, Bahlo M, Berkovic SF, Petrou S, Scheffer IE, Gecz J., Neurology. November 8, 2016; 87 (19): 1975-1984.

Extracellular Linkers Completely Transplant the Voltage Dependence from Kv1.2 Ion Channels to Kv2.1., Elinder F, Madeja M, Zeberg H, Århem P., Biophys J. October 18, 2016; 111 (8): 1679-1691.

A recurrent mutation in KCNA2 as a novel cause of hereditary spastic paraplegia and ataxia., Helbig KL, Hedrich UB, Shinde DN, Krey I, Teichmann AC, Hentschel J, Schubert J, Chamberlin AC, Huether R, Lu HM, Alcaraz WA, Tang S, Jungbluth C, Dugan SL, Vainionpää L, Karle KN, Synofzik M, Schöls L, Schüle R, Lehesjoki AE, Helbig I, Lerche H, Lemke JR., Ann Neurol. October 1, 2016; 80 (4):     

Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel., Oelstrom K, Chanda B., Nat Commun. May 17, 2016; 7 11608.

Positive Allosteric Modulation of Kv Channels by Sevoflurane: Insights into the Structural Basis of Inhaled Anesthetic Action., Liang Q, Anderson WD, Jones ST, Souza CS, Hosoume JM, Treptow W, Covarrubias M., PLoS One. November 24, 2015; 10 (11): e0143363.                    

Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy., Maity S, Mazzolini M, Arcangeletti M, Valbuena A, Fabris P, Lazzarino M, Torre V., Nat Commun. May 12, 2015; 6 7093.              

Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels., Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ., Elife. January 6, 2015; 4 e06774.                

A self-consistent approach for determining pairwise interactions that underlie channel activation., Chowdhury S, Haehnel BM, Chanda B., J Gen Physiol. November 1, 2014; 144 (5): 441-55.              

Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels., Chowdhury S, Haehnel BM, Chanda B., J Gen Physiol. November 1, 2014; 144 (5): 457-67.            

Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel., Zaydman MA, Kasimova MA, McFarland K, Beller Z, Hou P, Kinser HE, Liang H, Zhang G, Shi J, Tarek M, Cui J., Elife. March 12, 2014; 3 e03606.                        

Electrophysiological characterization of Ts6 and Ts7, K⁺ channel toxins isolated through an improved Tityus serrulatus venom purification procedure., Cerni FA, Pucca MB, Peigneur S, Cremonez CM, Bordon KC, Tytgat J, Arantes EC., Toxins (Basel). February 28, 2014; 6 (3): 892-913.              

A functional Kv1.2-hERG chimaeric channel expressed in Pichia pastoris., Dhillon MS, Cockcroft CJ, Munsey T, Smith KJ, Powell AJ, Carter P, Wrighton DC, Rong HL, Yusaf SP, Sivaprasadarao A., Sci Rep. February 26, 2014; 4 4201.              

Aromatic-aromatic interactions between residues in KCa3.1 pore helix and S5 transmembrane segment control the channel gating process., Garneau L, Klein H, Lavoie MF, Brochiero E, Parent L, Sauvé R., J Gen Physiol. February 1, 2014; 143 (2): 289-307.                      

Drug-induced ion channel opening tuned by the voltage sensor charge profile., Ottosson NE, Liin SI, Elinder F., J Gen Physiol. February 1, 2014; 143 (2): 173-82.              

Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating., Zhang Q, Zhou P, Chen Z, Li M, Jiang H, Gao Z, Yang H., Proc Natl Acad Sci U S A. December 10, 2013; 110 (50): 20093-8.

Multiple mechanisms underlying rectification in retinal cyclic nucleotide-gated (CNGA1) channels., Arcangeletti M, Marchesi A, Mazzolini M, Torre V., Physiol Rep. November 1, 2013; 1 (6): e00148.                        

Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels., Perry MD, Wong S, Ng CA, Vandenberg JI., J Gen Physiol. September 1, 2013; 142 (3): 275-88.                    

Activation of lysophosphatidic acid receptor by gintonin inhibits Kv1.2 channel activity: involvement of tyrosine kinase and receptor protein tyrosine phosphatase α., Lee JH, Choi SH, Lee BH, Hwang SH, Kim HJ, Rhee J, Chung C, Nah SY., Neurosci Lett. August 26, 2013; 548 143-8.

Pharmacological characteristics of Kv1.1- and Kv1.2-containing channels are influenced by the stoichiometry and positioning of their α subunits., Al-Sabi A, Kaza SK, Dolly JO, Wang J., Biochem J. August 15, 2013; 454 (1): 101-8.

Fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics., Sand R, Sharmin N, Morgan C, Gallin WJ., J Biol Chem. April 5, 2013; 288 (14): 9686-9695.

Molecular mechanism of voltage sensing in voltage-gated proton channels., Gonzalez C, Rebolledo S, Perez ME, Larsson HP., J Gen Physiol. March 1, 2013; 141 (3): 275-85.              

Characterization of a ligand binding site in the human transient receptor potential ankyrin 1 pore., Klement G, Eisele L, Malinowsky D, Nolting A, Svensson M, Terp G, Weigelt D, Dabrowski M., Biophys J. February 19, 2013; 104 (4): 798-806.

Homology model and targeted mutagenesis identify critical residues for arachidonic acid inhibition of Kv4 channels., Heler R, Bell JK, Boland LM., Channels (Austin). January 1, 2013; 7 (2): 74-84.              

A conserved pre-block interaction motif regulates potassium channel activation and N-type inactivation., Pfaffinger PJ., PLoS One. January 1, 2013; 8 (11): e79891.                  

A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel., Pless SA, Niciforovic AP, Galpin JD, Nunez JJ, Kurata HT, Ahern CA., Nat Commun. January 1, 2013; 4 1784.              

Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1., Aidery P, Kisselbach J, Schweizer PA, Becker R, Katus HA, Thomas D., Gene. December 10, 2012; 511 (1): 26-33.        

Intermediate state trapping of a voltage sensor., Lacroix JJ, Pless SA, Maragliano L, Campos FV, Galpin JD, Ahern CA, Roux B, Bezanilla F., J Gen Physiol. December 1, 2012; 140 (6): 635-52.                      

Molecular mechanism for depolarization-induced modulation of Kv channel closure., Labro AJ, Lacroix JJ, Villalba-Galea CA, Snyders DJ, Bezanilla F., J Gen Physiol. November 1, 2012; 140 (5): 481-93.                  

Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel., Wu S, Gao W, Xie C, Xu X, Vorvis C, Marni F, Hackett AR, Liu Q, Zhou L., J Gen Physiol. July 1, 2012; 140 (1): 29-39.            

Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway., Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M., J Biol Chem. November 11, 2011; 286 (45): 39091-9.

R1 in the Shaker S4 occupies the gating charge transfer center in the resting state., Lin MC, Hsieh JY, Mock AF, Papazian DM., J Gen Physiol. August 1, 2011; 138 (2): 155-63.                  

An electrostatic potassium channel opener targeting the final voltage sensor transition., Börjesson SI, Elinder F., J Gen Physiol. June 1, 2011; 137 (6): 563-77.                

A multipoint hydrogen-bond network underlying KcsA C-type inactivation., Cordero-Morales JF, Jogini V, Chakrapani S, Perozo E., Biophys J. May 18, 2011; 100 (10): 2387-93.

Mode shift of the voltage sensors in Shaker K+ channels is caused by energetic coupling to the pore domain., Haddad GA, Blunck R., J Gen Physiol. May 1, 2011; 137 (5): 455-72.            

A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel., Zarrabi T, Cervenka R, Sandtner W, Lukacs P, Koenig X, Hilber K, Mille M, Lipkind GM, Fozzard HA, Todt H., J Biol Chem. December 10, 2010; 285 (50): 39458-70.                        

Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel., Pantazis A, Kohanteb AP, Olcese R., J Gen Physiol. December 1, 2010; 136 (6): 645-57.              

Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics., Arcisio-Miranda M, Muroi Y, Chowdhury S, Chanda B., J Gen Physiol. November 1, 2010; 136 (5): 541-54.                

Overlapping binding sites of structurally different antiarrhythmics flecainide and propafenone in the subunit interface of potassium channel Kv2.1., Madeja M, Steffen W, Mesic I, Garic B, Zhorov BS., J Biol Chem. October 29, 2010; 285 (44): 33898-905.

Induction of vertebrate regeneration by a transient sodium current., Tseng AS, Beane WS, Lemire JM, Masi A, Levin M., J Neurosci. September 29, 2010; 30 (39): 13192-200.                    

Fast and slow voltage sensor rearrangements during activation gating in Kv1.2 channels detected using tetramethylrhodamine fluorescence., Horne AJ, Peters CJ, Claydon TW, Fedida D., J Gen Physiol. July 1, 2010; 136 (1): 83-99.                      

Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins., Chen P, Dendorfer A, Finol-Urdaneta RK, Terlau H, Olivera BM., J Biol Chem. May 14, 2010; 285 (20): 14882-14889.

Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix., Zhou Y, Tang QY, Xia XM, Lingle CJ., J Gen Physiol. May 1, 2010; 135 (5): 481-94.                  

Transfer of ion binding site from ether-a-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening., Lin MC, Abramson J, Papazian DM., J Gen Physiol. May 1, 2010; 135 (5): 415-31.                    

Activation of Slo2.1 channels by niflumic acid., Dai L, Garg V, Sanguinetti MC., J Gen Physiol. March 1, 2010; 135 (3): 275-95.                                

Mutations reveal voltage gating of CNGA1 channels in saturating cGMP., Martínez-François JR, Xu Y, Xu Y, Lu Z., J Gen Physiol. August 1, 2009; 134 (2): 151-64.                      

Divalent cations slow activation of EAG family K+ channels through direct binding to S4., Zhang X, Bursulaya B, Lee CC, Lee CC, Chen B, Pivaroff K, Jegla T., Biophys J. July 8, 2009; 97 (1): 110-20.

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