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Summary Expression Phenotypes Gene Literature (60) GO Terms (6) Nucleotides (46) Proteins (26) Interactants (73) Wiki

Papers associated with p2rx7

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Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain., Durner A, Durner E, Nicke A., Elife. January 4, 2023; 12

Activation of endothelial NO synthase and P2X7 receptor modification mediates the cholinergic control of ATP-induced interleukin-1β release by mononuclear phagocytes., Richter K, Asci N, Singh VK, Yakoob SH, Meixner M, Zakrzewicz A, Liese J, Hecker A, Wilker S, Stumpf S, Schlüter KD, Rohde M, Gödecke A, Padberg W, Manzini I, Schmalzing G, Grau V., Front Immunol. January 1, 2023; 14 1140592.                              

Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling., Whyte-Fagundes P, Taskina D, Safarian N, Zoidl C, Carlen PL, Donaldson LW, Zoidl GR., Commun Biol. May 18, 2022; 5 (1): 472.

Derivation and Characterization of Murine and Amphibian Müller Glia Cell Lines., Gallo RA, Qureshi F, Strong TA, Lang SH, Pino KA, Dvoriantchikova G, Pelaez D., Transl Vis Sci Technol. April 1, 2022; 11 (4): 4.        

A Simplified Protocol to Incorporate the Fluorescent Unnatural Amino Acid ANAP into Xenopus laevis Oocyte-Expressed P2X7 Receptors., Durner A, Nicke A., Methods Mol Biol. January 1, 2022; 2510 193-216.

Established Protocols for cRNA Expression and Voltage-Clamp Characterization of the P2X7 Receptor in Xenopus laevis Oocytes., Schmalzing G, Markwardt F., Methods Mol Biol. January 1, 2022; 2510 157-192.

Dissecting activation steps in P2X7 receptors., Gusic M, Benndorf K, Sattler C., Biochem Biophys Res Commun. September 10, 2021; 569 112-117.

Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation., Calzaferri F, Narros-Fernández P, de Pascual R, de Diego AMG, Nicke A, Egea J, García AG, de Los Ríos C., J Med Chem. February 25, 2021; 64 (4): 2272-2290.

Design, Synthesis, and in vitro Evaluation of P2X7 Antagonists., T Pournara D, Durner A, Kritsi E, Papakostas A, Zoumpoulakis P, Nicke A, Koufaki M., ChemMedChem. December 15, 2020; 15 (24): 2530-2543.

Dissection of P2X4 and P2X7 Receptor Current Components in BV-2 Microglia., Trang M, Schmalzing G, Müller CE, Markwardt F., Int J Mol Sci. November 11, 2020; 21 (22):   

Identification of aurintricarboxylic acid as a potent allosteric antagonist of P2X1 and P2X3 receptors., Obrecht AS, Urban N, Schaefer M, Röse A, Kless A, Meents JE, Lampert A, Abdelrahman A, Müller CE, Schmalzing G, Hausmann R., Neuropharmacology. November 1, 2019; 158 107749.

Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization., McCarthy AE, Yoshioka C, Mansoor SE., Cell. October 17, 2019; 179 (3): 659-670.e13.                              

SLPI Inhibits ATP-Mediated Maturation of IL-1β in Human Monocytic Leukocytes: A Novel Function of an Old Player., Zakrzewicz A, Richter K, Zakrzewicz D, Siebers K, Damm J, Agné A, Hecker A, McIntosh JM, Chamulitrat W, Krasteva-Christ G, Manzini I, Tikkanen R, Padberg W, Janciauskiene S, Grau V., Front Immunol. April 4, 2019; 10 664.

Comparative Embryonic Spatio-Temporal Expression Profile Map of the Xenopus P2X Receptor Family., Blanchard C, Boué-Grabot E, Massé K., Front Cell Neurosci. January 1, 2019; 13 340.                    

Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region., Huo H, Fryatt AG, Farmer LK, Schmid R, Evans RJ., J Biol Chem. August 17, 2018; 293 (33): 12820-12831.                

Interaction of Purinergic P2X4 and P2X7 Receptor Subunits., Schneider M, Prudic K, Pippel A, Klapperstück M, Braam U, Müller CE, Schmalzing G, Markwardt F., Front Pharmacol. May 26, 2017; 8 860.                        

Two P2X1 receptor transcripts able to form functional channels are present in most human monocytes., López-López C, Jaramillo-Polanco J, Portales-Pérez DP, Gómez-Coronado KS, Rodríguez-Meléndez JG, Cortés-García JD, Espinosa-Luna R, Montaño LM, Barajas-López C., Eur J Pharmacol. December 15, 2016; 793 82-88.

Phosphocholine - an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors., Richter K, Mathes V, Fronius M, Althaus M, Hecker A, Krasteva-Christ G, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz A, Grau V., Sci Rep. June 28, 2016; 6 28660.            

Homodimeric anoctamin-1, but not homodimeric anoctamin-6, is activated by calcium increases mediated by the P2Y1 and P2X7 receptors., Stolz M, Klapperstück M, Kendzierski T, Detro-Dassen S, Panning A, Schmalzing G, Markwardt F., Pflugers Arch. October 1, 2015; 467 (10): 2121-40.

Contribution of the Juxtatransmembrane Intracellular Regions to the Time Course and Permeation of ATP-gated P2X7 Receptor Ion Channels., Allsopp RC, Evans RJ., J Biol Chem. June 5, 2015; 290 (23): 14556-66.                

Lidocaine preferentially inhibits the function of purinergic P2X7 receptors expressed in Xenopus oocytes., Okura D, Horishita T, Ueno S, Yanagihara N, Sudo Y, Uezono Y, Minami T, Kawasaki T, Sata T., Anesth Analg. March 1, 2015; 120 (3): 597-605.

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages., Ousingsawat J, Wanitchakool P, Kmit A, Romao AM, Jantarajit W, Schreiber R, Kunzelmann K., Nat Commun. February 5, 2015; 6 6245.

Activation, permeability, and inhibition of astrocytic and neuronal large pore (hemi)channels., Hansen DB, Ye ZC, Calloe K, Braunstein TH, Hofgaard JP, Ransom BR, Nielsen MS, MacAulay N., J Biol Chem. September 19, 2014; 289 (38): 26058-26073.

Connexin hemichannel and pannexin channel electrophysiology: how do they differ?, Patel D, Zhang X, Veenstra RD., FEBS Lett. April 17, 2014; 588 (8): 1372-8.

ATP and potassium ions: a deadly combination for astrocytes., Jackson DG, Wang J, Keane RW, Scemes E, Dahl G., Sci Rep. February 26, 2014; 4 4576.                  

The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1., Wang J, Jackson DG, Dahl G., J Gen Physiol. May 1, 2013; 141 (5): 649-56.              

Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, potentiates ATP-gated P2X₁ receptor channel currents., Choi SH, Kim HJ, Kim BR, Shin TJ, Hwang SH, Lee BH, Lee SM, Rhim H, Nah SY., Mol Cells. February 1, 2013; 35 (2): 142-50.

P2X4 receptor channels form large noncytolytic pores in resting and activated microglia., Bernier LP, Ase AR, Boué-Grabot E, Séguéla P., Glia. May 1, 2012; 60 (5): 728-37.

P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties., Compan V, Ulmann L, Stelmashenko O, Chemin J, Chaumont S, Rassendren F., J Neurosci. March 21, 2012; 32 (12): 4284-96.

The effect of anions on the human P2X7 receptor., Kubick C, Schmalzing G, Markwardt F., Biochim Biophys Acta. December 1, 2011; 1808 (12): 2913-22.

Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action., Marques-da-Silva C, Chaves MM, Castro NG, Coutinho-Silva R, Guimaraes MZ., Br J Pharmacol. July 1, 2011; 163 (5): 912-26.

Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor., Baqi Y, Hausmann R, Rosefort C, Rettinger J, Schmalzing G, Müller CE., J Med Chem. February 10, 2011; 54 (3): 817-30.

Purinergic receptor-mediated Ca signaling in the olfactory bulb and the neurogenic area of the lateral ventricles., Hassenklöver T, Schulz P, Peters A, Schwartz P, Schild D, Manzini I., Purinergic Signal. December 1, 2010; 6 (4): 429-45.                

Effects of protons on macroscopic and single-channel currents mediated by the human P2X7 receptor., Flittiger B, Klapperstück M, Schmalzing G, Markwardt F., Biochim Biophys Acta. May 1, 2010; 1798 (5): 947-57.

A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice., Nicke A, Kuan YH, Masin M, Rettinger J, Marquez-Klaka B, Bender O, Górecki DC, Murrell-Lagnado RD, Soto F., J Biol Chem. September 18, 2009; 284 (38): 25813-22.

The pannexin 1 channel activates the inflammasome in neurons and astrocytes., Silverman WR, de Rivero Vaccari JP, Locovei S, Qiu F, Carlsson SK, Scemes E, Keane RW, Dahl G., J Biol Chem. July 3, 2009; 284 (27): 18143-51.

Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis., Roberts JA, Valente M, Allsopp RC, Watt D, Evans RJ., J Neurochem. May 1, 2009; 109 (4): 1042-52.              

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP., Qiu F, Dahl G., Am J Physiol Cell Physiol. February 1, 2009; 296 (2): C250-5.

Homotrimeric complexes are the dominant assembly state of native P2X7 subunits., Nicke A., Biochem Biophys Res Commun. December 19, 2008; 377 (3): 803-8.

The P2X7 carboxyl tail is a regulatory module of P2X7 receptor channel activity., Becker D, Woltersdorf R, Boldt W, Schmitz S, Braam U, Schmalzing G, Markwardt F., J Biol Chem. September 12, 2008; 283 (37): 25725-34.

P2X7 receptor-Pannexin1 complex: pharmacology and signaling., Iglesias R, Locovei S, Roque A, Alberto AP, Dahl G, Spray DC, Scemes E., Am J Physiol Cell Physiol. September 1, 2008; 295 (3): C752-60.

Influence of extracellular monovalent cations on pore and gating properties of P2X7 receptor-operated single-channel currents., Riedel T, Schmalzing G, Markwardt F., Biophys J. August 1, 2007; 93 (3): 846-58.

Kinetics of P2X7 receptor-operated single channels currents., Riedel T, Lozinsky I, Schmalzing G, Markwardt F., Biophys J. April 1, 2007; 92 (7): 2377-91.

Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor., Acuña-Castillo C, Coddou C, Bull P, Brito J, Huidobro-Toro JP., J Neurochem. April 1, 2007; 101 (1): 17-26.

Characterization of ATP-gated P2X7 receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1 beta., López-Castejón G, Young MT, Meseguer J, Surprenant A, Mulero V., Mol Immunol. February 1, 2007; 44 (6): 1286-99.

A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages., Shemon AN, Sluyter R, Fernando SL, Clarke AL, Dao-Ung LP, Skarratt KK, Saunders BM, Tan KS, Gu BJ, Fuller SJ, Britton WJ, Petrou S, Wiley JS., J Biol Chem. January 27, 2006; 281 (4): 2079-86.

Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels., Silberberg SD, Chang TH, Swartz KJ., J Gen Physiol. April 1, 2005; 125 (4): 347-59.                

An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor., Gu BJ, Sluyter R, Skarratt KK, Shemon AN, Dao-Ung LP, Fuller SJ, Barden JA, Clarke AL, Petrou S, Wiley JS., J Biol Chem. July 23, 2004; 279 (30): 31287-95.

Dissecting individual current components of co-expressed human P2X1 and P2X7 receptors., Seyffert C, Schmalzing G, Markwardt F., Curr Top Med Chem. January 1, 2004; 4 (16): 1719-30.

P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region., Smart ML, Gu B, Panchal RG, Wiley J, Cromer B, Williams DA, Petrou S., J Biol Chem. March 7, 2003; 278 (10): 8853-60.

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